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The virucidal effect against murine norovirus and feline calicivirus as surrogates for human norovirus by ethanol-based sanitizers |
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| Authors: | Yuko Shimizu-Onda Tempei Akasaka Fumihiro Yagyu Shihoko Komine-Aizawa Yukinobu Tohya Satoshi Hayakawa Hiroshi Ushijima |
| Affiliation: | 1. Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo, 173-8610, Japan 2. Department of Research and Development, Niitaka Co., Ltd, Osaka, Japan 3. Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan 4. Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kanagawa, Japan |
| Abstract: | This study examined the virucidal effects of five types of alcohol-based sanitizers including malic acid and sodium malate, or monoethanolamin, in 58 vol % ethanol (pH 4.0, pH 7.1, pH 11.8), 65 vol % ethanol (pH 4.2), and 75 vol % ethanol (pH 4.4) against murine norovirus (MNV) and feline calicivirus (FCV). The virus titer of MNV was reduced in an ethanol dose-dependent manner under the same pH (about 4.0) condition. Virucidal effect against MNV was correlated with pH when the concentration of ethanol was constant (58 vol %). All the ethanol-based sanitizers provided sufficient virucidal effects against FCV. In conclusion, the virucidal effect of the ethanol-based sanitizer at low concentration of ethanol against norovirus (NoV) is increased when the pH is adjusted to a neutral state. |
| Keywords: | Murine norovirus Feline calicivirus Surrogate Ethanol-based sanitizer |
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