静吸复合麻醉对颅内手术患者麻醉用量及不良反应的影响

目的探讨静吸复合麻醉对颅内手术患者麻醉用量及不良反应的影响。方法选取我院2012年1月至2012年12月采取静吸复合麻醉方式行颅内手术患者60例,随机分成A、B、C三组,分别给予患者不同麻醉用量,观察不同麻醉用量麻醉效果和不良反应情况。结果 A组不良反应3例,发生率为15.0%,B组9例(30.0%),C组21例(70.0%);A组和B组麻醉效果差异明显(P<0.05),B组和C组麻醉效果比较无显著差异(P>0.05)。结论对于采取静吸复合麻醉方式行颅内手术患者,2～3μg/mL血浆靶浓度丙泊酚复合4～6ng/mL血浆靶浓度瑞芬太尼与3～5μg/ml丙泊酚复合6～8ng/mL血浆靶浓度瑞芬太尼麻醉效果与无明显差异,不良反应较少,值得进一步研究和临床推广应用。

Static Absorption Dosage of Compound Anesthesia in Patients with Intracranial Surgery Anesthesia and the Impact of Adverse Reactions

Objective To study the static absorption dosage of compound anesthesia in patients with intracranial surgery anesthesia and the impact of adverse reactions. Methods From January 2012- December 2012 static absorption compound anesthesia ways line of 60 patients with intracranial surgery, were randomly divided into A, B, C three groups and were given different dosage of anesthetic patients, observe the different dosage of anesthetic effects and adverse reactions. Results Incidence of adverse reactions for group A, group B 9 cases （30.0%）, 21 cases of group C （70.0%）; Clear difference anesthetic effect in group A and group B （P〈0.05）, group B and group C anesthesia effect is no significant difference （P〉0.05）. Conclusion To adopt static absorption line compound anesthesia of intracranial surgery patients, 2-3 μg/mL plasma concentration of propofol target compound 4, 6 ng/mL target plasma concentration, fentanyl and 3-5μg/mL propofol compound 6-8 ng/mL, fentanyl anesthesia target plasma concentration effect and no obvious difference, with less adverse reactions, worthy of further research and clinical application.