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前列腺衰老逃逸现象的实验研究
引用本文:潘铁军,孟祥宝,叶章群. 前列腺衰老逃逸现象的实验研究[J]. 中华泌尿外科杂志, 2006, 27(Z1): 126-127
作者姓名:潘铁军  孟祥宝  叶章群
作者单位:1. 430070,武汉,广州军区武汉总医院泌尿外科
2. 华中科技大学同济医学院附属同济医院泌尿外科
摘    要:目的探讨良性前列腺增生(BPH)衰老逃逸现象的机理。方法采用端粒重复片段扩增法(TRAP)分别检测13例正常前列腺组织、35例BPH组织及33例增生结节和包膜的端粒酶活性表达情况,比较端粒酶活性水平与BPH衰老逃逸的关系。结果正常前列腺组织中端粒酶阳性2例(15%),BPH组织中端粒酶阳性17例(49%),增生结节端粒酶阳性14例(42%),包膜阳性1例(3%);BPH组织端粒酶阳性表达率高于正常前列腺组织(P<0.05),增生结节阳性率明显高于包膜组织(P<0.01)。结论BPH组织中端粒酶活性升高,且分布不均匀。提示前列腺衰老逃逸可能与端粒酶活性有关。

关 键 词:良性前列腺增生  端粒酶  衰老逃逸
修稿时间:2005-06-07

Study of senile escaping phenomenon in prostatic tissues
PAN Tie-jun,MENG Xiang-bao,YE Zhang-qun. Study of senile escaping phenomenon in prostatic tissues[J]. Chinese Journal of Urology, 2006, 27(Z1): 126-127
Authors:PAN Tie-jun  MENG Xiang-bao  YE Zhang-qun
Abstract:Objective To study the mechanism of senile escaping of benign prostatic hyperplasia(BPH) condition. Methods With polymerase chain reaction based telomeric repeat amplification protocol assay(TRAP),telomerase activity was examined in 13 normal prostate tissues,35 benign prostatic hyperplasia tissues,33 hyperplastic tubercle and diaphragm. Results Telomerase activity was detected in 2 of 13(15%)normal prostate tissues,17 of 35(49%)benign hyperplasia tissues,14 of 33(42%)hyperplastic tubercle tissues and 1 of 33(3%)diaphragm tissues.The positive rate of telomerase in BPH is higher than normal prostate (P<0.05);positive reaction different in hyperplastic tubercle and diaphragm,marked in hyperplastic tubercle(P<0.01). Conclusions It was shouwed that telomerase activity increase in BPH tissue and they distribute unevent.The mechanism of benign prostatic hyperplasia may be related to the expression of telomerase activity.
Keywords:Benign prostatic hyperplasia  Telomerase  Senile escaping
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