| 急性白血病一氧化氮合酶表达与多药耐药的关系 |
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| 引用本文： | 祝焱,谢兆霞.急性白血病一氧化氮合酶表达与多药耐药的关系[J].中南大学学报(医学版),2004,29(1):25-27. |
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| 作者姓名： | 祝焱 谢兆霞 |
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| 作者单位： | 中南大学湘雅医院血液科,长沙41008;中南大学湘雅医院血液科,长沙41008 |
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| 基金项目： | 卫生部资助课题 (0 60 73 0 1 4) |
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| 摘 要： | 目的：探讨急性白血病（AL）患者NOS表达与Pgp/mdr-1的关系。方法：采用免疫组织化学法检测iNOS，eNOS，Pgp表达；RT-PCR检测iNOS基因，mdr-1基因表达。结果：AL患者NOS表达较对照升高， iNOS与Pgp/mdr-1基因表达之间呈高度正相关（r=0.680，P<0.01）。结论：NO对AL多药耐药可能有一定影响。
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| 关 键 词： | 白血病 急性 一氧化氮 一氧化氮合酶 多药耐药 |
| 文章编号： | 1672-7347(2004)01-0025-03 |
| 收稿时间： | 2004-01-01 |
| 修稿时间： | 2004年1月1日 |
Nitric oxide synthase expression and multiple drug resistance in patients with acute leukemia |
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| ZHU Yan,XIE Zhao-xia.Nitric oxide synthase expression and multiple drug resistance in patients with acute leukemia[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),2004,29(1):25-27. |
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| Authors: | ZHU Yan XIE Zhao-xia |
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| Institution: | Department of Hematology， Xiangya Hospital, Central South University, Changsha 41008,China |
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| Abstract: | Objective To determine the relationship between nitric oxide synthase (NOS) expression and Pgp/mdr-1. Methods The expressions of iNOS, eNOS, and Pgp were detected by immunohistochemistry, and the expressions of iNOS gene and mdr-1 gene were detected by RT-PCR.Results NOS expression increased in patients with acute leukemia compared with that of the controls. There was some correlation between iNOS and Pgp/mdr-1 gene expression. Conclusion NO may influcence multiple drug resistance in patients with acute leukemia. |
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| Keywords: | leukemia acute nitric oxide nitric oxide synthase multiple drug resistance |
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