HLA class II associations in juvenile Graves' disease: indication of a strong protective role of the DRBl*0701, DQAl*0201 haplotype |
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| Authors: | L Lavard H O Madsen H Perrlld B B Jacobsen A Svejgaard |
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| Institution: | Department of Paediatrics, Glostrup University Hospital;Department of Clinical Immunology, National University Hospital (Rigshospitaiet), Copenhagen;Department of Internal Medicine, Bispebjerg Hospital;Department of Paediatrics, Odense University Hospital, Denmark |
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| Abstract: | Previous studies have shown that HLA-DRB1*0301 and DQA1*0501 are associated with susceptibility to Graves' disease. Ninety Danish patients with early onset of Graves' disease and 102–192 controls were analyzed for HLA-DR and -DQ to investigate if the same associations exist in the juvenile form of Graves' disease. Both DRB1*0301 and DQA1*0501 were highly significantly increased in the patients with relative risks of 8.0 and 4.6, which are higher than those seen in adults. Stratification showed that DRB1*0301 is more strongly associated than DQA1*0501. Surprisingly, the DRB1*0701, DQA1*0201 haplotype was completely absent from this group of patients, indicating a strong protective role of this haplotype in juvenile Graves' disease. |
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| Keywords: | juvenile Graves' disease HLA disease association protective HLA type |
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