| 胰岛素与阿尔茨海默病 |
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| 引用本文： | 崔佩菁,陈生弟. 胰岛素与阿尔茨海默病[J]. 上海交通大学学报(医学版), 2008, 28(12): 1587-1589 |
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| 作者姓名： | 崔佩菁 陈生弟 |
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| 作者单位： | [1]上海交通大学医学院瑞金医院老年科,上海200025 [2]上海交通大学医学院瑞金医院神经科上海阿尔茨海默病中心,上海200025 |
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| 摘 要： | 近年来，阿尔茨海默病（AD）的发病率呈明显增加的趋势，但其发病机制仍不明确。胰岛素及其受体被认为可能与AD的发病有关。文章就胰岛素与脑内葡萄糖代谢的关系以及胰岛素、胰岛素受体和胰岛素抵抗与AD发病的关系及其可能机制进行综述，并介绍AD的治疗进展。
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| 关 键 词： | 胰岛素 阿尔茨海默病 发病机制 |
Insulin and Alzheimer''s disease |
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| CUI Pei-jing,CHEN Sheng-di. Insulin and Alzheimer''s disease[J]. Journal of Shanghai Jiaotong University:Medical Science, 2008, 28(12): 1587-1589 |
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| Authors: | CUI Pei-jing CHEN Sheng-di |
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| Affiliation: | 1.Department of Gerontology;2.Department of Neurology;Shanghai Alzheimer's Disease Center;Ruijin Hospital;School of Medicine;Shanghai Jiaotong University;Shanghai 200025;China |
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| Abstract: | Recently,the incidence of Alzheimer's disease has been significantly increasing.However,the pathogenesis of Alzheimer's disease remains unknown.It is presumed that insulin and insulin receptor may be involved in the pathogenesis of Alzheimer's disease.The relationship between insulin and cerebral glucose metabolism,the relationship between insulin,insulin receptor,insulin resistance and pathogenesis of Alzheimer's disease as well as the possible mechanism are reviewed in this paper,and the progress of treat... |
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| Keywords: | insulin Alzheimer's disease pathogenesis |
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