| 国产尼美舒利的药效学研究 |
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| 引用本文： | 裘军 陈邦银. 国产尼美舒利的药效学研究[J]. 中国药理学通报, 1993, 9(6): 468-471 |
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| 作者姓名： | 裘军 陈邦银 |
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| 作者单位： | 同济医科大学药学院 武汉430030(裘军，陈邦银，张进芳，李高)，同济医科大学生殖医学中心药理实验室 武汉430030(吴熙瑞) |
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| 摘 要： | 本文研究了国产尼美舒利在小鼠、大鼠及家兔体内的抗炎、镇痛和解热作用.结果表明.尼美舒利抑制巴豆油致小鼠耳廓肿胀(ED_(50)为49.2mg·kg~(-1));抑制角叉菜胶致大鼠足肿(ED_(50)为2.75mg·kg(-1));0.6mg·kg~(-1)剂量对大鼠佐剂关节炎有显著预防和治疗作用。100mg·kg~(-1)对小鼠醋酸扭体法的抑制率为68％;对热板法致痛的痛阈提高率为55％。ip给药对蛋白胨致家兔发热的解热作用.其最小有效剂量为2mg·kg~(-1);5mg·kg~(-1)ig可显著降低啤酒酵母致大鼠升高的体温.证实国产尼美舒利具有很强的抗炎、镇痛和解热作用。
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| 关 键 词： | 尼美舒利 非甾体抗炎药 药效学 |
Studies on pharmacodynamics of domestic Nimesulide |
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| QIU Jun,CHEN Bang-Yin,ZHANG Jin-Fuang. Studies on pharmacodynamics of domestic Nimesulide[J]. Chinese Pharmacological Bulletin, 1993, 9(6): 468-471 |
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| Authors: | QIU Jun CHEN Bang-Yin ZHANG Jin-Fuang |
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| Abstract: | Nimesulide is a new non-steroidal anti-inflammatory drug (NSAID). In this paper, its antiinflammatory, analgesic and antipyretic effects in mice rat or rabbit were evaluated. Nimesulide inhibited the ear oedema induced by croton oil in mice (ED50=49. 2 mg · kg-1). It inhibitated rat hind paw oedema induced by carragreenin (ED50= 2.75 mg · kg-1). Oral dose (0. 6 mg · kg-1) showed sup-pressive effect on adjuvant arthritis in rat. Oraldose (100 mg · kg-1) decreased writhing induced by acetic acid. Similar effect was observed in hot plate test on mice. Nimesulide (2 mg · kg-1) decreased body tempreture elevated by injecting peptone in rabbit (P<0. 05). Body tempreture elevated by injecting yeast in rat was reduced also by used dose of Nimesulide of 5 mg · kg-1(P<0. 01). |
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| Keywords: | Nimesulide non-steroidal antiinflammatory drug pharmacodynamics |
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