氟比洛芬酯超前镇痛在全麻下扁桃体摘除术的应用

目的探讨氟比洛芬酯超前镇痛在全麻下扁桃体摘除术的应用。方法ASAI-Ⅱ级,择期行全麻下扁桃体摘除术患者60例,随机分为两组,每组30例。Ⅰ组(观察组)患者麻醉诱导前静脉缓慢注射氟比洛芬酯注射液100mg;Ⅱ组(对照组)不注射氟比洛芬翻注射液.分别记录两组患者术后2、6、12、24h的疼痛视觉模拟评分(VAS);咽喉疼痛发生率以及麻醉镇痛相关的不良反应;术毕时,术后12h和术后24h各取外周血2mL,检测PGE_2(前列腺素E_2)浓度.结果观察组术后2、6,12h VAS明显低于对照组(P<0.01),两组术后24hVAS比较差异无显著意义(P>0.05),两组与麻醉镇痛有关的不良反应之间比较无显著意义(P>0.05),但咽痛发生率观察组低于对照组(P<0.05)。两组术毕时和术后12h时前列腺素E_2浓度观察组低于对照组(P<0.01);术后24h时前列腺素E_2浓度两组之间差异无显著意义(P>0.05);观察组术后24h前列腺素E_2浓度比术毕和术后12h时要高(P<0.01).结论氟比洛芬酯超前镇痛应用于全麻下扁桃体摘除术,能有效缓解术后早期疼痛,减轻炎症反应.

The preemptive analgesia effect of flurbiprofen in the patients undergoing tonsillectomy under general anaesthesia

Objective To discuss the preemptive analgesia effect of flurbiprofen in the patients undergoing tonsillectomy under general anaesthesia.Methods 60 patients with ASAI-Ⅱscheduled for tonsillectomy were randomly divided into 2 groups.GroupⅠwas injected with flurbiprofen 100mg intravenously before anaesthesia induction.GroupⅡwas as control.The VAS,soar throat and side effects associated with anaesthesia were recorded 2,6,12 and 24h after operation.The levels of PGE_2 in peripheral blood were measured at the end of operation,12h after operation and 24h after operation.Results The VAS score of groupⅠwas significantly lower than that of groupⅡat 2,6,12 after operation(P<0.01).There was not significanfly difference between both groups at 24h after operation(P>0.05).The side effects associated with anaesthesia were not significantly differences between both groups,but the rates of soar throat in groupⅠwere significantly lower than that in groupⅡ(P<0.05).The levels of PGE_2 in groupⅠwere significantly lower than that of groupⅡat the end of operation,and 12h after opera,on(P<0.01).There were no differences between both groups in levels of PGE_2 at 24h after operation(P>0.05):The levels of PGE2 at 24h after operation in groupⅠwere significantly higher than that at the end of operation and 12h after operation(P<0.01).Conclusion Flurbiprofen preemptively applying in tonsillectomy can relieve the analgesia and inflammatorial reaction in early after operation.