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Serum levels of osteopontin as a prognostic factor in patients with oral squamous cell carcinoma |
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| Authors: | Maryam Mardani Azadeh Andisheh-Tadbir Bijan Khademi Mohammad Javad Fattahi Shapour Shafiee Maryam Asad-Zadeh |
| Affiliation: | 1. Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran 2. Oral and Dental Health Care Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran 6. Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Ghom Abad, Ghasrodasht Avenue, Shiraz, Iran 3. Department of Otolaryngology, Khalili Hospital, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran 4. Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran 5. School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran |
| Abstract: | Osteopontin (OPN) is a multifunctional glycophosphoprotein that was detected in many carcinomas, and it may have a prognostic role. The aim of this study was to determine osteopontin serum levels in patients with oral squamous cell carcinoma (OSCC) and investigated its correlation with clinicopathological features of tumor. Using an ELISA kit, we assessed and compared the circulating levels of OPN in blood serum of 45 oral squamous cell carcinoma patients with 45 healthy control samples. The serum osteopontin level in patients with OSCC was significantly higher (145.8?±?14.6 ng/ml, n?=?45) compared with the healthy controls (53.9?±?9.6 ng/ml, n?=?45, p?p?=?0.03) and higher stage (p?=?0.02). Findings of the present study suggest that OPN may have a potential role in pathogenesis of OSCC and it may be used as a tool for monitoring tumor progression. |
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