Clinical significance of serum circulating insulin-like growth factor-1 (IGF-1) mRNA in hepatocellular carcinoma |
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Authors: | S. Karabulut D. Duranyıldız F. Tas U. Gezer F. Akyüz M. Serilmez E. Ozgür C. T. Yasasever S. Vatansever N. F. Aykan |
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Affiliation: | 1. Department of Medical Oncology, Oncology Institute, Istanbul University, Istanbul, Turkey 4. Institute of Oncology, Istanbul University, Capa, 34390, Istanbul, Turkey 2. Department of Basic Oncology, Oncology Institute, Istanbul University, Istanbul, Turkey 3. Department of Gastroenterology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
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Abstract: | The principal aim of our study was to investigate the usefulness of serum protein and circulating mRNA of insulin-like growth factor-1 (IGF-1) as a diagnostic and prognostic tool in hepatocellular carcinoma (HCC). Fifty-four HCC patients and age- and sex-matched 20 healthy controls were enrolled into this study. Pretreatment serum IGF-1 and IGF-1 mRNA were determined by the solid-phase sandwich ELISA and quantitative RT-PCR method, respectively. The median age at diagnosis was 60 years, range 36–77 years; where majority of group were male (n?=?48, 88.8 %). All patients had cirrhotic history. Forty-six percent (n?=?25) of patients had Child-Pugh score A, 30 % (n?=?16) had score B or C. All of the patients were treated with local therapies and none of them received sorafenib. The baseline serum IGF-1 mRNA levels were significantly higher in HCC patients than in the control group (p?=?0.04), whereas no significant difference was observed for IGF-1 protein levels between the two group (p?=?0.18). Patients with history of HBV infection, who were not treated, and who received multiple palliative treatment for HCC had higher serum IGF-1 mRNA levels (p?=?0.03, 0.03, and 0.05, respectively). Poor performance status (p?0.001), viral etiology of cirrhosis (p?=?0.03), larger tumor size (p?=?0.01), lower serum hemoglobin levels (p?=?0.03), and not be treated for HCC (p?=?0.001) related to worse survival. However, neither serum IGF-1 nor serum IGF-1 mRNA had significantly adverse effect on survival (p?=?0.53 and 0.42, respectively). |
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