Quantitative assessment of the influence of CYP1B1 polymorphisms and head and neck squamous cell carcinoma risk |
| |
Authors: | Ming Shen Yuan-Yuan Hu Yu-Kun Hu Long-Chuan Xie Xiao-Ming Xu Ming-Yue Wu Yu-Ming Niu |
| |
Affiliation: | 1. Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, People’s Republic of China 2. Department of Stomatology and Evidence-Based Medicine Center, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China 3. Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People’s Republic of China 4. Stomatologic Hospital and College, Anhui Medical University, Hefei, 230032, People’s Republic of China
|
| |
Abstract: | The associations between CYP1B1 polymorphisms and head and neck squamous cell carcinoma (HNSCC) risk have been conflicting. We therefore performed a meta-analysis to derive a more precise relationship. Six published case–control studies were collected; odds ratios (ORs) with 95 % confidence interval (CI) were used to assess the association between CYP1B1 Leu432Val, Asn453Ser polymorphisms, and HNSCC risk. The Sensitivity analysis and publication bias also were performed to guarantee the statistical power. Overall, the pooled OR with 95 % CIs indicated that CYP1B1 Leu432Val polymorphism was significantly related with HNSCC risk (for Val vs. Leu: OR = 1.13, 95 % CI = 1.03–1.25, P?=?0.014, P heterogeneity?=?0.141; for Val/Val vs. Leu/Leu: OR = 1.30, 95 % CI = 1.06–1.60, P?=?0.013, P heterogeneity?=?0.253; for Val/Val vs. Leu/Leu + Leu/Val: OR = 1.23, 95 % CI = 1.05–1.46, P?=?0.013, P heterogeneity?=?0.456). The similar results were also been found in succeeding analysis of HWE and stratified analysis of Caucasian population. Furthermore, no significant association between CYP1B1 Asn453Ser polymorphism and HNSCC risk was found in this meta-analysis. In conclusion, our meta-analysis demonstrates that CYP1B1 Leu432Val polymorphism may be a risk factor for developing HNSCC. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|