儿童与青少年房间隔缺损介入治疗并发症随访研究

目的观察儿童与青少年无症状房间隔缺损患者行房间隔缺损介入治疗并发症发生情况,探讨不同年龄患者行封堵术治疗的安全性及可靠性。方法将50例房间隔缺损患者分为儿童组及青少年组,采用国产先健牌封堵器及其输送系统封堵房间隔缺损。比较两组封堵术成功率及监测术前、术后ECG、血常规、肝肾功能变化,随访术后并发症发生情况。结果青少年组与儿童组介入封堵成功率差异无统计学意义;儿童组术后近期并发症发生率高于青少年组,差异有统计学意义（χ2=4.5,P=0.03）,远期（1～6个月）并发症两组比较差异无统计学意义。两组术前、术后血常规、肝肾功能无明显变化。结论房间隔缺损介入治疗无症状的青少年房间隔缺损疗效较好,低年龄病例易发生并发症,大部分并发症在随访过程中（术后6个月）完全恢复,用大直径封堵器患者易出现房室传导阻滞。

Follow up of postoperative complications after interventional therapy for atrial septal defect in children and adolescent

Objective To observe postoperative complication after interventional therapy for atrial septal defect （ASD） in asymptomatic children and adolescent patients.Safety and reliability were compared in two group patients.Methods 50 cases of ASD patients were divided into children group and adolescences group.Both group patients were accepted transcatheter closure of ASD.Achievement ratio of ASD closure was statistics in both groups,The changes of ECG,blood routine,liver and renal function were monitored before and after interventional therapy.Postoperative complications were followed up in tow groups.Results Achievement ratio of interventional therapy in adolescent group was higher than in children group while postoperative complications in children group was higher than in adolescent group.Blood routine,liver and renal function had no marked change before and after interventional therapy in both groups.Conclusion Both curative effect and security after interventional therapy in asymptomatic adolescent ASD patients were higher than in asymptomatic children patients.There have versatility factors need careful consider in low age patients when use interventional therapy.