Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction |
| |
| Authors: | Ohkawara Bisei Shirakabe Kyoko Hyodo-Miura Junko Matsuo Ritsuko Ueno Naoto Matsumoto Kunihiro Shibuya Hiroshi |
| |
| Affiliation: | Department of Molecular Cell Biology, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, and CREST, JST, Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan. |
| |
| Abstract: | Transforming growth factor (TGF)-beta-activated kinase 1 (TAK1) and Nemo-like kinase (NLK) function in Xenopus, Drosophila, and Caenorhabditis elegans development. Here we report that serine phosphorylation of STAT3 induced by TAK1-NLK cascade is essential fo TGF-beta-mediated mesoderm induction in Xenopus embryo. Depletion of TAK1, NLK, or STAT3 blocks TGF-beta-mediated mesoderm induction. Coexpression of NLK and STAT3 induces mesoderm by a mechanism that requires serine phosphorylation of STAT3. Activin activates NLK, which in turn directly phosphorylates STAT3. Moreover, depletion of either TAK1 or NLK inhibits endogenous serine phosphorylation of STAT3. These results provide the first evidence that TAK1-NLK-STAT3 cascade participates in TGF-beta-mediated mesoderm induction. |
| |
| Keywords: | TAK1 NLK STAT3 TGF-β signal mesoderm induction |
| 本文献已被 PubMed 等数据库收录！ |
|
