| 感冒丸质量标准的研究 |
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| 引用本文： | 刘柏龙,杨锡,张冬慧. 感冒丸质量标准的研究[J]. 中国药事, 2009, 23(9): 878-880 |
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| 作者姓名： | 刘柏龙 杨锡 张冬慧 |
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| 作者单位： | 1. 甘肃省药品检验所,兰州,730000
2. 兰州大学 |
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| 基金项目： | 国家药品标准提高行动计划 |
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| 摘 要： | 目的提高完善感冒丸的质量标准。方法采用显微鉴别处方中的桑叶、薄荷、甘草。采用TLC法对处方中麻黄、桔梗进行定性鉴别;并用HPLC法对制剂中黄芩有效成分黄芩苷进行含量测定,色谱柱：广州菲罗门luna C18;流动相：甲醇-0.4%磷酸溶液（47∶53）;流速：1mL.min-1,柱温：30℃,检测波长：280nm。结果HPLC法测定黄芩苷在0.2042~2.042μg范围内有良好线性关系,r=0.9999。平均回收率为96.7%,RSD为1.06%（n=6）。结论定性、定量方法简便、可靠、准确、专属性强,可用于感冒丸的质量控制。
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| 关 键 词： | 感冒丸 TLC HPLC 质量标准 |
Study on Quality Standard for Ganmao Wan |
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| Affiliation: | Liu Bailong, Yang Xi and Zhang Donghui ( Gansu Institute for Drug Control, Lanzhou 730000;Lanzhou University) |
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| Abstract: | Objective To improve the quality standard for Ganmao wan. Methods The presence of Radix Platycodonis, Flos Lonicerae Japonicae, Radix Peucedani and Herba Ephedrae was identified by TLC. The content of Radix Scutellariaβ-D-Gluopyranosiduronic acid, 5, 6-dihydroxy-4-oxo-2-phenyl-4H-1- benzopyran-7-yl was determined by HPLC. Guangdong phenomenex C18 column was adoped. The mobile phase consisted of methanol -0.4%phosphoric acid（47 ： 53） and the detection wavelength was 280nm. The column temperature was 30℃. The flow rate was 1mL · min^-1. Results The good linear ranges of baicalin was 0. 2042-2. 042μg （r= 0. 9999）. The average recovery was 96.7% （n = 6） and RSD was 1.06%. Conclusions This method is simple, accurate and reliable. It can be used as a quantitative determination method for the quality control of Ganmao Wan. |
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| Keywords: | TLC HPLC |
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