| 单因素法优化两面针提取工艺 |
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| 引用本文： | 赵森,慕杨娜,姜黎,邹明.单因素法优化两面针提取工艺[J].世界中医药,2015,10(11). |
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| 作者姓名： | 赵森 慕杨娜 姜黎 邹明 |
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| 作者单位： | 1 大连大学附属中山医院，大连，116001； 2 辽宁中医药大学附属第二医院，沈阳，110032 |
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| 摘 要： | 目的：优化两面针药材的提取工艺。方法：采用单因素考察方法，以提取时间，提取次数，提取溶剂、用量、浓度及PH值作为优选因素，以两面针中的氯化两面针碱提取量和出膏率作为定量指标，优化提取工艺。结果：最佳的提取工艺条件是：乙醇浓度80%，加醇量为8倍，提取2次，每次提取2 h，加入0.1 mol/L盐酸调乙醇pH至5，出膏率和有效成分提取率比较高，重现性好。结论：优化的提取工艺稳定可行，适合工业大生产要求。
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| 关 键 词： | 两面针 总生物碱 单因素法 高效液相色谱 |
| 收稿时间： | 2014/8/19 0:00:00 |
Single-factor Optimization for Extraction Process of Radix Zanthoxyli |
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| Zhao Sen,Mu Yangn,Jiang Li,Zou Ming.Single-factor Optimization for Extraction Process of Radix Zanthoxyli[J].World Chinese Medicine,2015,10(11). |
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| Authors: | Zhao Sen Mu Yangn Jiang Li Zou Ming |
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| Institution: | 1 Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China; 2 The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110034, China |
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| Abstract: | To optimize extraction process of Radix zanthoxyli. Methods:By using a single factor optimization method, we selected a reasonable extraction process via ethyl alcohol. Optimizing factors are extraction time, number of extractions, extraction solvent, dosage, concentration, PH value; using yield rate and Nitidine Chloride extracted weight as parameters. Results:The optimum extraction process is 80% concentration of ethyl alcohol, extract 2 h each time, extract twice, controlling pH=5 using 0.1 mL/L HCL. Conclusion:The optimized extraction process is suitable for industrial production. |
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| Keywords: | Radix Zanthoxyli Total alkaloid Single factor optimization method HPLC |
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