活动期类风湿关节炎患者血清可溶性细胞间粘附分子-1 E-选择素变化及意义

目的　测定活动期类风湿关节炎 (RA)患者血清中可溶性细胞间粘附分子 (sICAM) 1、可溶性E 选择素 (sE 选择素 )、白细胞介素 (IL) 1、肿瘤坏死因子 (TNF)、干扰素 (IFN) γ水平 ,探讨sICAM 1、sE 选择素与IL 1、TNF、IFN γ及病情的关系。方法　用酶联免疫分析法 (ELISA)检测 3 0例活动期RA患者与 3 0名正常对照者sICAM 1、sE 选择素、IL 1、TNF、INF γ水平。结果　RA患者血清sICAM 1、sE 选择素、IL 1、TNF、IFN γ水平明显高于正常对照组 (P <0 0 0 1) ,sICAM 1与sE 选择素、IL 1、IFN γ水平及类风湿因子 (RF)正相关 ,sE 选择素与IL 1正相关。结论　RA患者血清sICAM 1、sE 选择素、IL 1、TNF、IFN γ水平显著升高 ,ICAM 1及sE 选择素参与RA发病过程 ,sICAM 1可作为判断病情严重性的指标

Clinical significance of serum sICAM-1 and sE-selectin in patients with active rheumatoid arthritis

Objective Measure the soluble forms of intercellular adhesive molecule-1 (sICAM-1),E-selectin and interleukin-1 (IL-1),tumor necrosis factor (TNF),interferon (IFN)-γ,study the role of sICAM-1 and sE-selectin in rheumatoid arthritis (RA).Methods A sandwich ELISA technique was used to measure the serum levels of sICAM-1,sE-selectin,IL-1,TNF,IFN-γ in 30 patients with active RA and 30 normal control subjects.Results The levels of sICAM-1 and sE-selectin in patients with RA were significantly higher than those in control subjects (P<0.001),at the same time,the level of sICAM-1 had positive correlation with that of sE-selectin,IL-1,IFN-γ and RF.The level of E-selectin had positive correlation with that of IL-1.Conclusion Patients suffering from RA showed significantly higher serum concentrations of sICAM-1,sE-selectin,IL-1,TNF,and IFN-γ.These findings suggest the possibility that ICAM-1 and E-selectin participate in the pathogenesis of RA;the level of sICAM-1 maybe judge illness condition.