| 蒲黄、维生素E和C对大鼠动脉内皮细胞合成前列环素与产生脂质过氧化物的影响 |
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| 引用本文： | 强卫国,张彩英,徐德敏. 蒲黄、维生素E和C对大鼠动脉内皮细胞合成前列环素与产生脂质过氧化物的影响[J]. 上海交通大学学报(医学版), 1987, 0(4) |
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| 作者姓名： | 强卫国 张彩英 徐德敏 |
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| 作者单位： | 上海第二医科大学基础部病理生理教研室(强卫国，张彩英)，上海第二医科大学基础部病理生理教研室(徐德敏) |
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| 摘 要： | 大鼠主动脉内皮细胞培养于含高脂兔血清的培养液中,分别加入含蒲黄的兔血清、维生素E和维生素C,孵育后,测定培养液中6-酮-PGF_(1α)(PGI_2代谢产物)及细胞中的丙二醛(脂质过氧化物的终产物)。结果,蒲黄兔血清能明显促进内皮细胞合成PGI_2,维生素E能明显降低内皮细胞产生脂质过氧化物,维生素C既能明显增高内皮细胞合成PGI_2,又能明显降低内皮细胞产生脂质过氧化物。故认为三种药物对防治动脉粥样硬化有理论与实践意义。
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| 关 键 词： | 内皮细胞 蒲黄 维生素E 维生素C 脂质过氧化物 6-酮-PGF_(1α) |
Effects of Pollen Typhae,Vitamin E and Vitamin C on the Synthesis of Prostacyclin and the Production of Lipid Peroxide by Cultured Rat Endothelial Cells |
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| Qiang Weiguo,et al. Effects of Pollen Typhae,Vitamin E and Vitamin C on the Synthesis of Prostacyclin and the Production of Lipid Peroxide by Cultured Rat Endothelial Cells[J]. Journal of Shanghai Jiaotong University:Medical Science, 1987, 0(4) |
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| Authors: | Qiang Weiguo et al |
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| Affiliation: | Qiang Weiguo,et al Department of Pathophysiology,Shanghai Second Medical University,Shanghai |
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| Abstract: | Rat endothelial cells were cultured in hyperlipemic sera with Pollen Typhae components, Vit E and Vii C separetely. Pollen Typhae and vitamin C significantly stimulated the synthesis of prostacyclin (determined as 6-oxo-PGF_(1a) by radioimmunoassay) by the cultured cells, Vitamin E and vitamin C markedly decreased the amount of MDA (malondialdehyde, the end product of lipid peroxides, determined by TBA reaction) in these cells. These results indicated that Pollen Typhae, vitamin E and vitamin C may have some beneficial effects in the prevention and treatment of atherosclerosis. |
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