Ku70蛋白在鼻咽癌中的表达及其临床意义

目的 探讨Ku70在鼻咽癌中的表达及其临床意义.方法 采用免疫组化SP法检测223例鼻咽癌石蜡标本中Ku70的表达情况,根据免疫反应强弱将其分为高表达和低表达两组(阴性表达归入低表达组),并结合临床资料分析Ku70表达高低与患者的临床病理特征及预后的关系.结果 Ku70在鼻咽癌组织中的高表达率为63.7%.单因素生存分析显示Ku70高表达组总生存率低于低表达组(x2=7.88,P=0.005),多因素分析显示性别、年龄、病理分型不是预后独立影响因素(x2=0.08、1.04、2.34,P=0.780、0.308、0.126),T、N、M分期是预后独立影响因素(x2=8.02、7.22、36.86,P=0.005、0.007、0.000),Ku70对鼻咽癌预后的独立影响接近临界值(x2=2.94,P=0.085).结论 初步研究发现Ku70对评价鼻咽痛的预后有参考价值,对患者预后的判断有一定的指导意义.

Expression and clinical significance of ku7O in nasopharyngeal carcinoma

Objective To investigate the expression and clinical significance of Ku70 in nasopha ryngeal oarcinoma(NPC).Methods The expression of Ku70 protein in 223 specimens of nasopharyngeal carcinoma was examined by immunohistochemistry.Based on the levels of ku70 immunoreactivities,the 223 specimens were divided into high Ku70 expression group and low Ku70 expression group.The correlation of Ku70 expression with clinicopathologic features and prognosis of NPC was analyzed according to the clinical data. Results The rate of high Ku70 expression was 63.7%.Univariate survival analysis suggested that the overall survival rate was significantly lower in high KuTO expression group than in low Ku70 expression group (X2 = 7.88,P = 0.005).Cox multivariate analysis indicated that T stage,N stage and M stage were the independent prognostic predictors (X2 = 8.02,7.22,36.86;P =0.005,0.007,0.000),but not with gender, age or pathological type(X2 = 0.08 ,1.04,2.34;P = 0.780,0.308,0.126),the influence of Ku70 on the o verall survival rate was close to critical value(P = 0.085).Conclusions Ku70 is positively expressed in the majority of NPC.KuT0 expression has significant correlations with T stage and N stage.The results of our study suggest that Ku70 is a valuable prognostic factor of NPC.