上腹部开放手术后氟比洛芬酯镇痛效果评价

目的：评价氟比洛芬酯用于上腹部开放手术患者的镇痛效果及不良反应。方法将40例上腹部手术患者随机分为实验组和对照组。实验组患者采用自控镇痛（patient controlled analgesia，PCA）方案：（60 mg吗啡＋200 mg氟比洛芬酯）/240 ml；对照组采用PCA方案：60 mg吗啡/240 ml。背景输注4 ml/h，单次给药量4 ml，锁定时间15 min。术后观察不同时间的视觉模拟镇痛评分（ VAS）、用药量及不良反应发生情况。结果两组患者不同时间点VAS评分、不良反应发生率之间差异无统计学意义，除4 h时药物使用量实验组小于对照组（P＜0．05）以外，其他时点的药物使用量比较无统计学差异。结论建议对上腹部开放手术患者不宜加用氟比洛芬酯。

Analgesic effect of flurbiprofen on patients receiving open abdominal surgery

Objective To evaluate the analgesic effect and side effects of flurbiproten on patients receiving open abdominal surgery.Methods Forty patients receiving open abdominal surgeries were randomized to different regimens of PCA .Study group PCA：60 mg morphine ＋200 mg flurbiproten/240 ml;control group PCA：60 mg morphine/240 ml.Background infusion rate：4 ml/h, bolus 4ml;lock time：15 mins.The VAS、drug doses consumption and side effects were evaluated .Results There were no differences between the VAS and side effects ,except the drug consumption at 4 hours after the operation; there were no differences between drug consumptions on the other time points .Conclusions Compared with the PCA with only morphine , PCA plus flurbiproten can not in-crease the analgesic effect , nor the morphine consumption .