血清 CEA、NSE、SCC-Ag与 CYFRA21-1联合检查对肺癌的诊断价值

目的：探讨癌胚抗原（carcinoembryonic antigen ，CEA）、神经元特异度烯醇化酶（neuron-specific enolase degree ， NSE）、磷状上皮细胞癌抗原（ squamous cell carcinoma antigen ，SCC-Ag）与细胞角蛋白19片段（ cytokeratin 19 fragment ，CY-FRA21-1）联合检查对肺癌的诊断价值。方法选取肺癌68例，同时选取良性肺疾病70例和健康体检人员90名作为对照组和健康组，分别应用全自动发光免疫分析仪开展血清检查，记录三组样本血清中的CEA、NSE、SCC-Ag与CYFRA21-1的含量，并进行比较分析。结果肺癌组的血清CEA、NSE、SCC-Ag与CYFRA21-1含量均显著高于其他两组，组间比较差异有统计学意义（ P＜0．05）。单一检测的特异性较高，与联合诊断比较无统计学差异，但联合诊断的灵敏度为80．9％，准确度为83．3％，均显著高于单一检测，差异有统计学意义（ P＜0．05）。结论血清CEA、NSE、SCC-Ag与CYFRA21-1的联合检查能有效提高肺癌诊断的敏感性和准确度，具有较好的诊断价值。

Value of clinical application of serum CEA,NSE, SCC-Ag and CYFRA21-1 in joint diag-nosis of lung cancer patients

Objective To investigate the joint clinical value of carcinoembryonic antigen （CEA）, neuron-specific enolase de-gree （NSE）, squamous cell carcinoma antigen （SCC-Ag） and cytokeratin 19 fragment （CYFRA21-1） in diagnosis of lung cancer pa-tients.Methods 68 patients with lung cancer in this hospital from September 2012 to August 2013 were recruited , while 70 patients with benign lung disease and 90 healthy people as controls ,underwent automated immunoassay analyzer serological test .Two samples of serum CEA, NSE, SCC-Ag and content CYFRA21-1 were recorded to conduct comparative analysis .Results After testing, serum CEA in lung cancer group , NSE, SCC-Ag and CYFRA21-1 levels were significantly higher than those in the other two groups , the difference was statistically significant （P〈0.05） between groups .The CEA level in adenocarcinoma was significantly higher than that in the other two types;NSE level in small cell lung cancer was significantly higher than that in the other two types ;SCC-Ag and CY-FRA21-1 levels in squamous cell carcinoma were significantly higher than those in the other two types , the differences were statistically significant （P〈0.05）.High single detection specificity had no significant difference in the joint diagnosis , but the combined diagnos-tic sensitivity was 80.9%and the accuracy was 83.3%, significantly higher than those in a single test , the difference was statistically significant （P〈0.05 ）.Conclusions The serum lung cancer patients carry CEA , NSE, SCC-Ag and CYFRA21-1 joint diagnosis could effectively improve the sensitivity and accuracy of disease diagnosis , with the exact value of clinical application .