Tei指数评价川崎病患儿心脏功能的临床意义

目的：应用Tei指数评价川崎病（ kawasaki disease ，KD）患儿心脏功能，探讨其临床意义。方法超声心动图测量KD急性期和恢复期患儿62例的左室射血分数（ EF）、左室短轴缩短率（ FS）、二尖瓣口舒张期血流E/A比值、肺静脉血流S/D比值、左右心室等容收缩期（ICT）、等容舒张期（IRT）、射血时间（ET）和计算左、右心室Tei指数，并与80例年龄、性别匹配的健康儿童作比较。结果 KD急性期左心室Tei指数较健康儿童明显增高（0．43±0．07 vs 0．37±0．06，P＜0．01），恢复期组左心室Tei指数减低，接近健康儿童（0．40±0．09 vs 0．37±0．06），差异无统计学意义；KD急性期右心室Tei指数增加，与健康对照组相比差异有统计学意义（0．31±0．06 vs 0．25±0．05，P＜0．01），恢复期组右心室Tei指数减低，逐渐接近正常（0．30±0．08 vs 0．25±0．05），差异无统计学意义。结论 KD急性期患儿存在心脏整体功能异常，Tei指数能准确、敏感地评价患儿心脏整体功能。

Evaluation of myocardial function impairment using the Tei index in patients with Ka-wasaki disease

Objective To investigate the clinical value of Tei index in the myocardial function in patients with Kawasaki dis -ease（KD）.Methods In the prospective study, 50 patients underwent echocardiogramphic evaluation .The left ventricular ejection fraction （EF）, shortening fraction （FS）, peak E/A ratio at mitral valve （E/A）, peak S/D ratio of pulmonary venous flow （S/D）, isovolumetric continuaction time （ICT）, isovolumetric relaxation time （IRT） and ejection time （ET） were measured.Tei index was calculated.As a control, we also assessed 72 healthy children, matched for age and sex with the study population .Results Compared with the control group , left ventricular Tei index was significantly increased in the children with acute KD guoup （0.44 ±0.07 vs 0.37 ±0.05,P〈0.01）.Tei index of KD group in convalescent stage was decreased （0.40 ±0.09 vs 0.37 ±0.05, P〉0.05）.Right ven-tricular Tei index was also significantly increased in the children with acute KD guoup （0.44 ±0.07 vs 0.37 ±0.05,P〈0.01） com-pared with the healthy children .And during the convalescent stage , the right ventricular Tei index tended to normal .Conclusions The ventricular global function was impaired in children with acute KD .Tei index is a accurate and sensitive tool for estimating global myocardial dysfunction in KD patients .