| 肝复康对阻塞性黄疸肝损害的预防作用的实验研究 |
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| 引用本文： | 秦冰,王忠裕.肝复康对阻塞性黄疸肝损害的预防作用的实验研究[J].中国现代医学杂志,2006,16(22):3424-3426,3430. |
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| 作者姓名： | 秦冰 王忠裕 |
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| 作者单位： | 1. 辽宁省营口市中心医院,普外科,辽宁,营口,115001
2. 大连医科大学附属第一医院,普外科,大连,116011 |
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| 摘 要： | 目的观察中药肝复康对实验性阻塞性黄疸所致肝损害的预防作用。方法实验分3组。Ⅰ组：假手术对照组，Ⅱ组：阻塞性黄疸组，Ⅲ组：肝复康预防治疗组。观察指标包括血清直接胆红素、丙氨酸转氨酶、血清内毒素、肝细胞浆内游离钙和肝脏组织病理学变化。结果Ⅱ组上述各指标水平均明显增高，而Ⅲ组均呈不同程度的低值，与Ⅱ组相比差异有显著性（P〈0.05）。肝脏组织病理学显示，预防应用肝复康能显著减轻肝细胞变性、坏死及纤维组织形成。结论肝复康用于阻塞性黄疸所致肝脏损害的预防，可将抗内毒素血症与拮抗肝细胞浆内游离钙离子浓度升高的作用结合起来，有望延缓肝损害的进程。
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| 关 键 词： | 肝复康 阻塞性黄疸 肝损害 大鼠 |
| 文章编号： | 1005-8982（2006）22-3424-03 |
| 收稿时间： | 2006-09-20 |
| 修稿时间： | 2006-09-20 |
Preventive effect of Gan-Fu-Kang on liver injury in experimental obstructive jaundice |
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| QIN Bing,WANG Zhong-yu.Preventive effect of Gan-Fu-Kang on liver injury in experimental obstructive jaundice[J].China Journal of Modern Medicine,2006,16(22):3424-3426,3430. |
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| Authors: | QIN Bing WANG Zhong-yu |
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| Institution: | 1.Depaartment of General Surgery, Yingkou Central Hospital, Yingkou, Liaoning 115001, P.R. China; 2. Department of General Surgeny, the 1st Affiliated, Dalian Medical University, Dalian, Liaoning 116011, P. R.China |
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| Abstract: | Objective To investigate the preventive effect of Gan-Fu-Kang on liver injury in experimental obstructive Jaundice.Methods SD rats were divided randomly into three groups:Group I,normal group;Group II,obstructive jaundice model group;Group III,Gan-Fu-Kang group.Serum endotoxin,intracellular free Ca2+ concentration and pathologic changes of the liver were observed.Results Elevated serum endotoxin and intracellular free Ca2+ concentration were markedly decreased and liver injure was also significantly alleviated when obstructive jaundice rats were intragastrically given Gab-Fu-Kang once a day.(P<0.05)Conclusion Gan-Fu-Kang showed effects not only on anti-endotoxemia,but also against intracellular free Ca2+.This herbal medicine can prevent the progress of liver injure. |
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| Keywords: | Gan-Fu-Kang obstructive jaundice liver injure rat |
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