血清尿酸水平与糖代谢状况及肌酐清除率的关系

目的探讨糖尿病（DM）高危人群在糖耐量正常（NGT）、糖调节受损（IGR）和新诊断DM状态下血尿酸（SUA）水平及其与肌酐清除率（Ccr）的关系，验证在DM人群中SUA水平下降与肾小球滤过率（GFR）升高相关的科学假设。方法对822例行糖耐量筛查患者按照糖代谢状态分成7组，比较SUA和Ccr的变化；用线性回归分析SUA和Ccr的变化趋势。结果（1）性别、BMI、TG、HbA1C和Ccr是影响SUA的独立因素。（2）IGR患者的SUA较NGT者高，DM患者的SUA较IGR患者低（P＜0．01），且低于NGT。而DM组的Ccr高于IGR组和NGT组（P＜0．01）。（3）当FPG＜7.0mmol／L时，SUA水平与FPG的升高不相关，当FPG≥7．0mmol／L时，随着FPG的升高，SUA明显下降（P＜0.01）；而Ccr在FPG≥6.0mmol／L时显著升高，在一定的范围内与FPG正相关（P＜0.01）。结论本研究肯定了先前报道的在中国新诊断T2DM人群中SUA降低的现象，并提示GFR的增高可能是导致该人群SUA降低的原因之一。

Relationship of serum uric acid level with the different states of glucose metabolism and creatinine clearance rate

Objective To explore the association of serum uric acid level with the different states of glucose metabolism and glomerular filtration rate (GFR) reflected by creatinine clearance rate and to test the hypothesis that increased GFR is one of the determinants of serum uric acid level. Methods 822 subjects with high risk factors for diabetes in Beijing area underwent a 75g oral glucose tolerance test (OGTT) for screening of diabetes. The subjects were divided into three groups:NGT,IGR and DM after OGTT. SUA a...