NMR determination of free gallium(III) ions in aqueous solutions of Ga complexes, “cold” analogs of PET/SPECT tracers |
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| Authors: | Q. Zhou C. Henoumont L. Vander Elst S. Laurent R.N. Muller |
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| Affiliation: | 1. Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, , Mons, B‐7000 Mons, Belgium;2. Center for Microscopy and Molecular Imaging (CMMI), Académie Wallonie‐Bruxelles, , Gosselies, B‐6041 Belgium |
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| Abstract: | Ga complexes are widely used as radiopharmaceuticals for PET or SPECT imaging and as therapeutic agents. At physiological pH, free gallium(III) ions can stably exist as soluble gallate [Ga(OH)4]?, a nephrotoxic compound whose presence should be avoided. Any Ga complex, therefore, should be carefully checked for the absence of gallate before use. Here we show that 71Ga NMR is a useful tool to rapidly detect the presence of gallate in aqueous solutions of Ga complexes and to follow the purification steps of the Ga complex solutions. Copyright © 2011 John Wiley & Sons, Ltd. |
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| Keywords: | Ga complexes [Ga(OH)4]− (gallate) 71Ga NMR PET SPECT |
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