聚谷氨酸苄酯的氨解及其共聚物表面血小板黏附研究

通过聚谷氨酸苄酯部分氨解的方法制备谷氨酸苄酯-羟乙谷氨酰胺共聚物，氨解时间越长，共聚物中羟乙谷氨酰胺含量越大，氨解后样品具有更高的亲水性，材料表面黏附的血小板有明显的减少，当共聚物中羟乙谷氨酰胺含量为0.133(摩尔分数）时，材料表面黏附的血小板为最小，所有共聚物的抗凝血性能都得到改善。

Study on Adhesion of Platelets to Surface of Copoly(Benzyl Glutamate-Hydroxy Ethyl Glutamine)

Copoly (benzyl glutamate-hydroxy ethyl glutamine) were prepared by partially aminolysis of poly benzyl glutamate with hydroxyl ethylamine at 60 degrees C for predeternined period. As aminolysis was proceeding, the content of hydroxy ethyl glutamine in copolymer increased and the yield of aminolysis decreased. When aminolysis time reached 16.5 hours, a copolymer with 0.357 mole fraction of hydroxy ethyl glutamine was obtained. After 16.5 hours a soluble yellow viscous product of reaction was obtained. The aminolysized specimens displayed more swelling degree in water, that is, more hydrophilits. The meassurement of solid-liquid contact angles showed that an increase in critical surface tention with content of hydroxy ethyl glutamine in copolymer was observed. Likewise a obvious increase in polar component and a slight decrease in dispersive of surface free energy, thus an increase in total surface free energy with content of hydroxy ethyl glutamine was found. The platelet adhesion and deformation test indicated that less platelets were adhered to surfaces of all aminolysized specimens than that of both poly benzyl glutamate and polydimethylsilicone. The least adhered platelets on surface of copolymer with 0.133 mole fraction of content of hydroxy ethyl glutamine were observed. The partiall aminolysis of poly benzyl glutamate films is an effective method to improve its hydrophility and antithrombogenicity.