Plasma and cerebrospinal fluid pharmacokinetics of thalidomide and lenalidomide in nonhuman primates期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Plasma and cerebrospinal fluid pharmacokinetics of thalidomide and lenalidomide in nonhuman primates

Authors:	Jodi?A.?Muscal,Yongkai?Sun,Jed?G.?Nuchtern,Robert?C.?Dauser,Leticia?H.?McGuffey,Brian?W.?Gibson,Stacey?L.?Berg author-information" > author-information__contact u-icon-before" > mailto:sberg@txch.org" title=" sberg@txch.org" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Texas Children’s Cancer Center, Baylor College of Medicine, 1102 Bates Street, Suite 1220, Houston, TX 77030, USA;(2) Celgene Corporation, Summit, NJ, USA;(3) Department of Surgery, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, USA;(4) Department of Neurosurgery, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, USA;(5) Center for Comparative Medicine, Baylor College of Medicine, Houston, TX, USA;

Abstract:	Purpose Thalidomide, originally developed as a sedative, was subsequently identified to have antiangiogenic properties. Lenalidomide is an antiangiogenic and immunomodulatory agent that has been utilized in the treatment of patients with brain tumors. We studied the pharmacokinetics and cerebrospinal fluid (CSF) penetration of thalidomide and lenalidomide in a nonhuman primate model.

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