Synthesis of novel 1-pyrazolylpyridin-2-ones as potential anti-inflammatory and analgesic agents |
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| Authors: | Ismail Magda M F Ammar Yousry A El-Zahaby Heba S A Eisa Sally I El-Sayed Barakat Saber |
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| Institution: | Pharmaceutical Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, Egypt. magda_f_ismail@yahoo.com |
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| Abstract: | A new series of 4-alkyl/aryl-2-oxo-1-pyrazolyl-1,2-dihydropyridine-3-carbonitriles, pyrazolo3,4-b]pyridine-5-carbonitriles and pyrido2,3-d]pyrimidine-6-carbonitriles have been synthesized and tested for their anti-inflammatory and analgesic activities. Among the tested compounds, 3e and 8b exhibited comparable anti-inflammatory activity to the standard (indomethacin). Compounds 5, 7a, and 8b displayed potent analgesic activity. Detailed syntheses, spectroscopic and biological data are reported. |
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| Keywords: | Analgesic activities Anti‐inflammatory Condensed pyridone 1‐Pyrazolylpyridin‐2‐one |
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