Morphological and functional imaging in COPD with CT and MRI: present and future |
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Authors: | Julia Ley-Zaporozhan Sebastian Ley Hans-Ulrich Kauczor |
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Institution: | (1) Department of Radiology (E010), German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;(2) Department of Pediatric Radiology, Ruprecht-Karls-University, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany;(3) Department of Diagnostic and Interventional Radiology, Johannes Gutenberg-University Hospital, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany |
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Abstract: | Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. COPD is defined
by irreversible airflow obstruction. It is a heterogeneous disease affecting the airways (i.e. chronic bronchitis, airway
collapse), the parenchyma (i.e. hyperinflation, air trapping and emphysematous destruction) as well as the vasculature (i.e.
hypoxic vasoconstriction, rarefication and pulmonary arterial hypertension) with different severity during the course of the
disease. These different aspects of COPD can be best addressed by imaging using a combination of morphological and functional
techniques. Three-dimensional high-resolution computed tomography (3D-HRCT) is the technique of choice for morphological imaging
of the lung parenchyma and airways. This morphological information is to be accomplished by functional information about perfusion,
regional lung mechanics, and ventilation mainly provided by MRI. The comprehensive diagnostic possibilities of CT complemented
by MRI will allow for a more sensitive detection, phenotype-driven characterization and dedicated therapy monitoring of COPD
as presented in this review. |
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Keywords: | COPD CT MRI Perfusion Ventilation |
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