| Significance of the Expression of Rho-GDP Dissociation Inhibitorβ,γin Lung Squamous Cell Carcinoma and Adenocarcinoma |
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| 引用本文： | 孙曼妮,李晓倩,周静怡,刘冬明,韩昱晨.Significance of the Expression of Rho-GDP Dissociation Inhibitorβ,γin Lung Squamous Cell Carcinoma and Adenocarcinoma[J].中国癌症研究,2007,19(4):287-290. |
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| 作者姓名： | 孙曼妮 李晓倩 周静怡 刘冬明 韩昱晨 |
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| 作者单位： | Department of Clinic Medicine Basic Medicine College，China Medical University，Department of Clinic Medicine，Basic Medicine College，China Medical University，Department of Medical Biology，Basic Medicine College，China Medical University，Department of Clinic Medicine，Basic Medicine College，China Medical University，Department of Pathology，Basic Medicine College，China Medical University，Shenyang 110011，Shenyang 110011，Shenyang 110011，Shenyang 110011，Shenyang 110011 |
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| 基金项目： | This work was supported by the Natural Sciences Foundation of LiaoNing province in2005(No.20052085) |
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| 摘 要： | Objective:To study the expression of Rho-GDP dissociation inhibitor β,γ(Rho-GDIβ,Rho-GDIγ)in lung squamous cell carcinoma and adenocarcinoma and its relationship with the expression of RhoC(Ras homologus oncogenes C)and clinicopathologic parameters.Methods:Western blot assay was employed for Rho-GDIβ,Rho-GDIγ and RhoC in lung squamous cell carcinoma and adenocarcinoma and non-neoplastic lung tissues of 37 cases with fresh specimens.Results:The study showed that Rho-GDIβ,Rho-GDIγ and RhoC were expressed in lung cancer and non-neoplastic lung tissues,the level in lung cancer tissue was much higher than that in non-neoplastic tissues(P<0.001).In lung cancer,the expression of Rho-GDIβ was much higher in patients with lymph node metastasis(P=0.021),and the expression of Rho-GDIγ was much higher in poorly differentiated tumor than in well-differentiated and moderately differentiated tumor,but both of them were not correlated with other clinicopathologic parameters.The expressions of Rho-GDIβ and Rho-GDIγ were not correlated with the expression of RhoC.Conclusion:In lung cancer,Rho-GDIβ and Rho-GDIγ may play a role in the tumorigenesis,Rho-GDIβ may promote metastasis,and Rho-GDIγ may have some relationship with differentiation.
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| 关 键 词： | Lung squamous cell carcinoma and adenocarcinoma Rho-GDIβ Rho-GDIγ RhoC |
| 文章编号： | 1000-9604（2007）04-04-0286 |
| 收稿时间： | 2007-09-19 |
| 修稿时间： | 2007-10-10 |
Significance of the expression of Rho-GDP dissociation inhibitorβ,γ in lung squamous cell carcinoma and adenocarcinoma |
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| Man-ni Sun,Xiao-qian Li,Zhou Jing-yi,Dong-ming Liu,Yu-chen Han.Significance of the expression of Rho-GDP dissociation inhibitorβ,γ in lung squamous cell carcinoma and adenocarcinoma[J].Chinese Journal of Cancer Research,2007,19(4):287-290. |
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| Authors: | Man-ni Sun Xiao-qian Li Zhou Jing-yi Dong-ming Liu Yu-chen Han |
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| Institution: | (1) Department of Clinic Medicine, Basic Medicine College, China Medical University, Shenyang, 110011, China;(2) Department of Medical Biology, Basic Medicine College, China Medical University, Shenyang, 110011, China;(3) Department of Pathology, Basic Medicine College, China Medical University, Shenyang, 110011, China |
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| Abstract: | Objective To study the expression of Rho-GDP dissociation inhibitor β, γ (Rho-GDIβ, Rho-GDIγ) in lung squamous cell carcinoma and adenocarcinoma
and its relationship with the expression of RhoC (Ras homologus oncogenes C) and clinicopathologic parameters.
Methods Western blot assay was employed for Rho-GDIβ, Rho-GDIγ and RhoC in lung squamous cell carcinoma and adenocarcinoma and non-neoplastic
lung tissues of 37 cases with fresh specimens.
Results The study showed that Rho-GDIβ, Rho-GDIγ and RhoC were expressed in lung cancer and non-neoplastic lung tissues, the level
in lung cancer tissue was much higher than that in non-neoplastic tissues (P<0.001). In lung cancer, the expression of Rho-GDIβ was much higher in patients with lymph node metastasis (P=0.021), and the expression of Rho-GDIγ was much higher in poorly differentiated tumor than in well-differentiated and moderately
differentiated tumor, but both of them were not correlated with other clinicopathologic parameters. The expressions of Rho-GDIβ
and Rho-GDIγ were not correlated with the expression of RhoC.
Conclusion In lung cancer, Rho-GDIβ and Rho-GDIγ may play a role in the tumorigenesis, Rho-GDIβ may promote metastasis, and Rho-GDIγ
may have some relationship with differentiation.
This work was supported by the Natural Sciences Foundation of LiaoNing province in 2005(No. 20052085) |
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| Keywords: | Lung squamous cell carcinoma and adenocarcinoma Rho-GDIβ Rho-GDIγ RhoC |
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