| 丰富环境对脑梗死大鼠梗死灶周围血管内皮生长因子受体的影响 |
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| 引用本文： | 马向阳,牟兆新,陈俊荣,穆剑玲,张小津,崔茂香,黄冬冬.丰富环境对脑梗死大鼠梗死灶周围血管内皮生长因子受体的影响[J].中国康复医学杂志,2010,25(2):109-113. |
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| 作者姓名： | 马向阳 牟兆新 陈俊荣 穆剑玲 张小津 崔茂香 黄冬冬 |
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| 作者单位： | 河北省沧州医学高等专科学校,沧州,061001 |
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| 摘 要： | 目的:研究丰富环境对大鼠局灶性脑梗死后梗死灶周围血管内皮生长因子受体的影响。方法:采用开颅电凝法制作SD大鼠右侧大脑中动脉缺血(MCAO)模型,术后第24小时随机分为丰富环境(EE)组和标准环境(SE)组。以免疫组织化学法检测血管内皮生长因子受体Flt-1及Flk-1的表达。结果:大鼠大脑中动脉闭塞后,缺血区神经元变性、坏死,Flt-1和Flk-1在缺血周边区表达明显增加,经丰富环境干预后,血管内皮生长因子受体表达大量增加。结论:丰富环境可促使血管内皮生长因子受体表达上调,进而促进微血管新生,有利于脑损伤修复。
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| 关 键 词： | 丰富环境 脑梗死 血管内皮生长因子受体 |
| 收稿时间： | 2009/3/29 0:00:00 |
Effect of enriched environment on vascular endothelial growth factor receptor expression around-infarction lesion in rats after unilateral local cerebral infarction |
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| MA Xiangyang,MU Zhaoxin,CHEN Junrong Cangzhou Medical College,Cangzhou.Effect of enriched environment on vascular endothelial growth factor receptor expression around-infarction lesion in rats after unilateral local cerebral infarction[J].China Journal of Rehabilitation Medicine,2010,25(2):109-113. |
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| Authors: | MA Xiangyang MU Zhaoxin CHEN Junrong Cangzhou Medical College Cangzhou |
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| Institution: | MA Xiangyang,MU Zhaoxin,CHEN Junrong Cangzhou Medical College,Cangzhou,061001 |
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| Abstract: | Objective:To evaluate the effect of enriched environment (EE) on vascular endothelial growth factor receptor (VEGFR) expression around infarction lesion in rats after unilateral local cerebral infarction.Method:The right middle cerebral artery occlusion(MCAO) was performed with electric coagulation in SD rats,then the models were randomly divided into enriched environment group (EE group) and standard environment group(SE group).The expression of VEGFR-1(Flt-1) and VEGFR-2 (Flk-1) in the boundary zone of ce... |
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| Keywords: | enriched environment cerebral ischemia vascular endothelial growth factor receptor |
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