急性脑梗死患者血清IL-1β、CRP含量动态变化研究

目的动态观察急性脑梗死患者血清白介素-1β(Interleukin-1β,IL-1β)、C-反应蛋白(C-reactive protein CRP)含量变化,探讨炎症因子在脑梗死发病机制中的作用。方法抽取33例急性脑梗死患者发病3d内、7d和14d时的空腹静脉血,采用双抗体夹心酶联免疫吸附法(enzyme-linkedimmunosorbent assay,ELISA)测定血清IL-1β的水平,免疫速率散射比浊法测定血清CRP水平,并与30名健康对照组比较。结果急性脑梗死患者发病3d内、7d和14d时血清IL-1β、CRP水平均显著高于正常对照组(P<0.05),其中发病3d内水平最高,随时间推移及治疗的介入,炎症因子水平逐渐下降;3d内测定的不同梗死体积患者血清IL-1β、CRP含量存在显著性差异(P<0.05);直线相关分析表明二者之间存在正相关。结论急性脑梗死患者血清IL-1β、CRP水平明显升高,并与急性脑梗死的体积密切相关,对炎症反应的干预治疗可能有利于减轻缺血性脑损害。

Study on the Changes of Serum Levels of Interleukin-1β(IL-1β) and C-Reactive Protein(CRP) in Patients with Acute Cerebral Infarction

Objective To explore the role of IL-1β and CRP in the pathogenesis of acute cerebral infarction.Methods Study included 33 patients with acute cerebral infarction and 30 healthy people as control.Serum IL-1β was measured by enzyme-linked immunosorbent assay(ELISA),and serum CRP was detected by the immune rate nephelometry.Results Compared with control group,the serum levels of IL-1β and CRP within 3 days,on the 7th day and 14th day in patients with acute cerebral infarction were increased significantly(P<0.05),with the levels within 3 days were the highest in patients with acute cerebral infarction.There was a positive correlation between the increasing degree of serum levels of IL-1β and CRP and the size of infarct area(P<0.05).Conclusions Serum IL-1β and CRP are increased significantly in patients with acute cerebral infarction,they possibly play a key role in the pathogenesis of acute cerebral infarction,therefore anti-inflammatory drugs maybe will become potential new therapeutic agents for acute cerebral infarction.