脂质代谢、尿酸与突发性聋的关系

目的探讨突发性聋与血清脂质代谢、血尿酸之间的关系。方法回顾性分析突发性聋住院患者100例的病史特点、血液学检查和影像学检查结果，检测其血清中甘油三酯、胆固醇、高密度胆固醇、低密度胆固醇、载脂蛋白ＡＩ、载脂蛋白Ｂ、血尿酸的含量。结果突发性聋组高密度胆固醇低于对照组，血尿酸值高于对照组，且差异有统计学意义（Ｐ<0.05），各年龄组之间的高密度胆固醇、尿酸值差异无统计学意义（Ｐ>0.05）。两组之间的甘油三酯、胆固醇、低密度胆固醇、载脂蛋白ＡＩ、载脂蛋白Ｂ值均差异无统计学意义。结论高密度胆固醇下降、 尿酸代谢紊乱是突发性聋发生的危险因素。

Relationship between lipid metabolism, uric acid and sudden sensorineurol hearing loss

To explore the relationship between changes of serum lipid metabolism, uric acid and sudden sensorineurol hearing loss(SSNHL). MethodsThe serum levels of triglyceride(TG), cholesterol(CHO), high density lipoprotein cholesterol(HDL CH), low density lipoprotein cholesterol(LDL CH), apolipoprotein AI(Apo AI), apolipoprotein B （Apo B）and uric acid（UA） in 100 patients with sudden sensorineurol hearing loss and 56 controls were determined. ResultsThe serum levels of high lipoprotein cholesterol were significantly decreased (P<0.05) and uric acid significantly increased (P<0.05) in the sudden sensorineural hearing loss group in comparison with the control group. There were no significant differences of high　lipoprotein cholesterol or uric acid in any age group, also there were no significant differences in levels of TG, CHO, LDL CH, AｐｏAI and AｐｏB between the sudden sensorineural hearing loss groups and the control groups（Ｐ>0.05）. ConclusionMetabolic disturbance of serum lipids and uric acid in patients with sudden sensorineurol hearing loss may be related to the etiology of sudden sensorineural hearing loss.