INCREASE OF ACTIVATED FACTOR VIIA AND HAEMOSTATIC MOLECULAR MARKERS IN JUVENILE CHRONIC ARTHRITIS |
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| Authors: | INAMO, Y. PEMBERTON, S. TUDDENHAM, E. G. D. WOO, P. |
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| Affiliation: | Sections of Molecular Rheumatology and Haemostasis Research Group, MRC Clinical Research Centre, Northwick Park Hospital Watford Road, Harrow HA 13UJ
*Department of Paediatrics, Nihon University School of Medicine Itabashi-ku, Tokyo 173, Japan |
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| Abstract: | Activated factor VIIa (FVIIa), von Willebrand factor antigen(vWF:Ag), D-dimer and thombin-antithrombin III complex (TAT)were measured to monitor coagulation status in patients withjuvenile chronic arthritis (JCA). Subjects included 14 patientswith systemic JCA, 16 with pauciarticular JCA and 16 with polyarticularJCA without disseminated intravascular coagulopathy, thrombosisor liver dysfunction. All types of JCA showed an increase ofFVIIa, D-dimer and TAT, indicating enhanced activation of coagulation.In systemic JCA only there was also characteristically an elevationof vWF:Ag. We conclude that all types of JCA constitute a stateof subclinical hypercoagulopathy caused by tissue damage andthat additionally systemic JCA involves a prothrombotic stateassociated with or precipitated by vasculitis. KEY WORDS: Factor VIIa, Juvenile chronic arthritis |
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