| 大肠癌中EGFR基因单核苷酸多态性及EGFR表达的分析 |
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| 引用本文： | 夏庆欣,庄競,王佳琪,李峰,陈壬寅,张豫峰. 大肠癌中EGFR基因单核苷酸多态性及EGFR表达的分析[J]. 医药论坛杂志, 2011, 0(18): 10-15 |
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| 作者姓名： | 夏庆欣 庄競 王佳琪 李峰 陈壬寅 张豫峰 |
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| 作者单位： | 河南省肿瘤医院;郑州大学附属肿瘤医院病理科;郑州大学附属肿瘤医院普外科;郑州大学第一附属医院病理科、河南省肿瘤病理重点实验室; |
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| 摘 要： | 目的 探讨表皮生长因子受体(epidermal growth factor receptor,EGFR)基因外显子13G64A单核苷酸多态性及EGFR蛋白表达与大肠癌的相关性.方法 应用PCR - RFLP法结合DNA测序法对72例大肠癌患者外周血DNA中EGFR基因的外显子13G64A单核苷酸多态性位点的等位基因进行...
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| 关 键 词： | 大肠癌 EGFR 单核苷酸多态性 PCR - RFLP |
Study of EGFR expression and single nucleotide polymorphism of EGFR gene in colorectal carcinoma |
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| XIA Qing-xin,ZHUANG Jing,WANG Jia-qi,LI Feng,CHEN Ren-yin,ZHANG Yu-feng. Study of EGFR expression and single nucleotide polymorphism of EGFR gene in colorectal carcinoma[J]. Journal of Medical Forum, 2011, 0(18): 10-15 |
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| Authors: | XIA Qing-xin ZHUANG Jing WANG Jia-qi LI Feng CHEN Ren-yin ZHANG Yu-feng |
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| Affiliation: | XIA Qing-xin,ZHUANG Jing,WANG Jia-qi,LI Feng,CHEN Ren-yin,ZHANG Yu-feng Department of Pathology,Henan Tumor Hospital,Zhengzhou 450003,China |
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| Abstract: | Objective To investigate the correlation between the single nucleotide polymorphism(SNP) in exon 13 G64A domain of epidermal growth factor receptor(EGFR) gene as well as EGFR expression and colorectal carcinoma.Methods Peripheral blood samples from 72 cases of colorectal carcinoma were detected for polymorphisms in exon 13 G64A domain by polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP) and DNA sequencing.EGFR expressions in tumor and adjacent normal tissues were observed by immun... |
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| Keywords: | Colorectal carcinoma Epidermal growth factor receptor Single nucleotide polymorphism PCR-RFLP |
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