| HPVL1壳蛋白联合HPV分型检测在诊断子宫颈病变中的作用 |
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| 引用本文： | 张露丹.HPVL1壳蛋白联合HPV分型检测在诊断子宫颈病变中的作用[J].医药论坛杂志,2011(19):17-19. |
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| 作者姓名： | 张露丹 |
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| 作者单位： | 郑州大学第二附属医院妇产科; |
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| 基金项目： | 河南省卫生厅科技人才创新工程资助项目:201004122 |
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| 摘 要： | 目的了解HPV L1壳蛋白联合HPV分型检测在诊断子宫颈病变中的作用。方法回顾性的对在郑州大学第二附属医院妇科门诊2010年7月—2011年1月进行HPV L1壳蛋白联合HPV分型检测的403例患者进行总结和分析。结果在HPV L1壳蛋白及HPV分型检测均(-)时没有CIN的出现;在HPV L1壳蛋白(+)而HPV分型检测(-)组中CINⅠ有5例占0.052%;HPV L1壳蛋白及HPV分型检测均(+)组中CINⅠ3例、CINⅡ2例共占0.086;在HPV L1壳蛋白(-)而HPV分型检测(+)组CINⅠ59例Ⅱ37例、CINⅢ26例及SCC 1例,分别各占42.75%、26.81%、18.84%及0.007%。HPV L1壳蛋白(-)而HPV分型检测(+)组与前3组比较差异有统计学意义(P<0.05)。结论宫颈癌筛查十分必要,HPV L1壳蛋白联合HPV分型检测在诊断宫颈癌前病变中具有重要的指导作用,HPV L1壳蛋白检测可以作为预测宫颈癌前病变进展的生物学标志物。。
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| 关 键 词： | 宫颈癌 HPV分型检测 人乳头状瘤病毒L1壳蛋白 |
HPV L1 protein unites HPV typing examination to diagnose cervical lesions |
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| ZHANG Lu-dan The Second Affililated Hospital of Zhengzhou University,Zhengzhou ,China.HPV L1 protein unites HPV typing examination to diagnose cervical lesions[J].Journal of Medical Forum,2011(19):17-19. |
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| Authors: | ZHANG Lu-dan The Second Affililated Hospital of Zhengzhou University Zhengzhou China |
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| Institution: | ZHANG Lu-dan The Second Affililated Hospital of Zhengzhou University,Zhengzhou 450000,China |
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| Abstract: | Objective To understind the HPV L1 protein unites HPV typinge examination to diagnose the cervix pathological change.Methods The review from July,2010 to January,2011 carries on HPV in the second affiliated hospital of Zhengzhou University gynecology department outpatient service the L1 protein to unite HPV examination 403 patients were summarized the analyzed.Results When HPV L1 protein and HPV typing examination(-)does not the found CIN 5 cases account for 0.052%;HPV L1 protein and HPV typing examination(... |
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| Keywords: | Cervical cancer Human papilloma virus(HPV)genotyping Human papilloma virus L1 protein |
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