| IP与EP方案治疗小细胞肺癌的比较研究 |
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| 引用本文： | 杨光华,陈运芳,赵富丽,苏春荣,吴春华,李琦. IP与EP方案治疗小细胞肺癌的比较研究[J]. 医药论坛杂志, 2011, 0(16): 54-55,58 |
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| 作者姓名： | 杨光华 陈运芳 赵富丽 苏春荣 吴春华 李琦 |
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| 作者单位： | 驻马店市中心人民医院肿瘤科; |
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| 摘 要： | 目的比较伊立替康加顺铂(CPT11+DDP)及依托泊苷加顺铂(VP16+DDP)两种方案一线治疗小细胞肺癌的临床疗效、不良反应。方法初治小细胞肺癌患者67例,IP组34例患者,应用DDP 40mg/m2静脉滴注,d1～d3,CPT～1160mg/m2静脉滴注,d1、d8、d15。EP组33例患者,应用方案DDP 40mg/m2静脉滴注,VP-16100mg/m2静脉滴注,d1～d5,两种方案均为28d为一个周期,连用4～6个周期。两个周期后评价疗效及不良反应。结果 IP组有效率58.8%,EP组有效率39.4%,两组比较差异有统计学意义(P<0.05);IP组无进展生存期4.1个月,EP组无进展生存期2.9个月,两组比较差异无统计学意义(P>0.05);两组不良反应发生率比较差异均无统计学意义,P>0.05。结论与依托泊泔联合顺铂方案相比,伊立替康联合顺铂方案疗效相似,不良反应相近,且无进展生存期延长,是小细胞肺癌一线治疗的安全有效方案。
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| 关 键 词： | 小细胞肺癌 顺铂/伊立替康 顺铂/依托泊苷 |
Clinical study of comparison of IP and EP for first-line treatment of small cell lung cancer |
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| YANG Guang-hua,CHEN Yun-fang,ZHAO Fu-li,SU Chun-rong,WU Chun-hua,LI Qi. Clinical study of comparison of IP and EP for first-line treatment of small cell lung cancer[J]. Journal of Medical Forum, 2011, 0(16): 54-55,58 |
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| Authors: | YANG Guang-hua CHEN Yun-fang ZHAO Fu-li SU Chun-rong WU Chun-hua LI Qi |
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| Affiliation: | YANG Guang-hua,CHEN Yun-fang,ZHAO Fu-li,SU Chun-rong,WU Chun-hua,LI Qi Department of Oncology,Zhumadian Central Hospital,Zhumadian,Henan 463000,China |
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| Abstract: | Objective To evaluate the efficacy and side effects between the Irinotecan+cisplatin(CPT11+DDP) and etoposide+cisplatin(VP16+DDP) for first-line treatment of small cell lung cancer(SCLC).Methods Sixty-seven SCLC patients untreated were divided into two groups(IP group and EP group).IP group(34 cases)were treated with DDP(40mg/m2) by intravenous infusion on the first 3 days and irinotecan(60mg/m2) on the first day,the 8th day and the 15th day.EP group(33cases) were treated in the same way with IP group and e... |
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| Keywords: | Small cell lung cancer Irinotecan/cisplatin Etoposide /cisplatin |
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