| 儿童特发性血小板减少性紫癜患者NK细胞及T淋巴细胞亚群变化及意义 |
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| 引用本文： | 李彦格,毛彦娜,李慧霞,张红梅,刘炜.儿童特发性血小板减少性紫癜患者NK细胞及T淋巴细胞亚群变化及意义[J].医药论坛杂志,2011(19):24-25. |
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| 作者姓名： | 李彦格 毛彦娜 李慧霞 张红梅 刘炜 |
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| 作者单位： | 郑州市儿童医院血液科; |
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| 摘 要： | 目的检测特发性血小板减少性紫癜(ITP)患者T淋巴细胞亚群及NK细胞的变化,探讨其在ITP发病机制中的作用。方法应用流式细胞术分别检测80例ITP及35例正常对照组T淋巴细胞亚群、NK细胞变化。结果 ITP患者CD3+、CD4+细胞百分比及CD4+/CD8+比值明显低于正常对照组(P<0.01),CD8+细胞百分比高于正常对照组(P<0.01)。NK细胞百分比明显低于正常对照组P<0.01)。结论及T淋巴细胞亚群及NK细胞的变化可较好的反映ITP的病理过程,对提高ITP的诊断水平及指导临床具有一定的使用价值。
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| 关 键 词： | 血小板减少性紫癜 T淋巴细胞亚群 NK细胞 |
Study on changes and clinical significance of lymphocyte subtypes and NK cells in children with idiopathic thrombocytopenic purpura |
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| LI Yan-ge,MAO Yan-na,LI Hui-xia,ZHANG Hong-mei,LIU Wei Dpartmendt of Hematology,Children's Hospiatl of Zhengzhou,Zhengzhou ,China.Study on changes and clinical significance of lymphocyte subtypes and NK cells in children with idiopathic thrombocytopenic purpura[J].Journal of Medical Forum,2011(19):24-25. |
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| Authors: | LI Yan-ge MAO Yan-na LI Hui-xia ZHANG Hong-mei LIU Wei Dpartmendt of Hematology Children's Hospiatl of Zhengzhou Zhengzhou China |
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| Institution: | LI Yan-ge,MAO Yan-na,LI Hui-xia,ZHANG Hong-mei,LIU Wei Dpartmendt of Hematology,Children's Hospiatl of Zhengzhou,Zhengzhou 450053,China |
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| Abstract: | Objective To test changes in T lymphocyte subsets and NK cells in patients with ITP and to discuss the related factors envolved in pathlgenesis of ITP.Methods Using flow cytometric analysis detect T lymphocyte and NK cells subtype in 80 patients with ITP and 35 heaithy controls.Resoits The percentage of CD3+ T lymphocyte and CD4+ T lymphocyte and the ratio of CD4+/CD8+ in patients with ITP were obviously lower than those in heaithy controls(P<0.01),but the percentage of CD8+ T lymphocyte was much higher(P<0... |
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| Keywords: | Thrombocytopenic purpura T lymphocyte subsets NK cells |
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