烧伤对外周血T淋巴细胞增殖和白细胞介素2产生的影响

目的　探讨烧伤患者伤后免疫功能紊乱的可能机制以及烧伤患者病情监测、免疫状况评估的观察指标。方法　检测4 0名正常志愿者和6 5例烧伤患者伤后不同时间外周血T淋巴细胞增殖反应和白细胞介素2 (IL 2 )产生能力。结果　中度以上烧伤后患者外周血T淋巴细胞增殖反应和IL 2产生能力开始下降,与对照组比较具有显著性差异(P <0 .0 5或P <0 .0 1) ,且IL 2产生能力与T淋巴细胞增殖反应基本相一致。结论　T淋巴细胞增殖反应和白细胞介素 2 (IL 2 )产生能力是影响烧伤患者免疫功能的众多原因中的重要原因之一,因此通过观察烧伤患者伤后外周血T淋巴细胞增殖反应和白细胞介素2 (IL 2 )产生能力对烧伤病情的监测及免疫状况的评估有一定的临床意义。

Enhancing effect on peripheral blood lymphocyte proliferation and interleukin-2 production in patients of burn

Objective To explore the possible mechanism of immune disorder, disease monitoring and observation indices for evaluating immune status in burns. Methods Sixty-five patients in the study were divided into four groups, the peripheral blood T lymphocyte (PBL) proliferation and interleukin-2 (IL-2) production in the severe burn patients were determined after burn injury and forty volunteers were employed to be normal control group for comparing the differences. Results The PBL proliferation and IL-2 production in the severe burn patients tended to fall after burn injury and there were significant differences when compared with the normal control group (P<0.05 or P<0.01). The peripheral blood T lymphocyte (PBL) proliferation and interleukin-2 (IL-2) production in the severe burn patients showed low level to the 20th day after severe burn injury while T lymphocyte (PBL) proliferation coincided with the change of IL-2 production. Conclusion PBL proliferation and IL-2 production can be one of the factors which produces immune regulatory effect on cell mediated immune function in patients of burn. Therefore observation of the peripheral blood T lymphocyte (PBL) proliferation and interleukin-2 (IL-2) production in the severe burn patients plays an important role in the monitoring of disease and observation indices for evaluating immune status in burns.