New insights into the role of angiotensin-converting enzyme obtained from the analysis of genetically modified mice |
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Authors: | Xiao Z Shen Hong D Xiao Ping Li Chentao X Lin Sandrine Billet Derick Okwan-Duodu Jon W Adams Ellen A Bernstein Yi Xu Sebastien Fuchs Kenneth E Bernstein |
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Institution: | (1) Department of Pathology, Emory University, Rm. 7107A WMB, 101 Woodruff Circle, Atlanta, GA 30322, USA |
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Abstract: | Angiotensin-converting enzyme (ACE) has been well-recognized for its role in blood pressure regulation. ACE is made by many
tissues, though it is most abundantly expressed on the luminal surface of vascular endothelium. ACE knockout mice show a profound
phenotype with low blood pressure, but also with hemopoietic and developmental defects, which complicates understanding the
biological functions of ACE in individual tissue types. Using a promoter-swapping strategy, several mouse lines with unique
ACE tissue expression patterns were studied. These include mice with ACE expression in the liver (ACE 3/3), the heart (ACE
8/8), and macrophages (ACE 10/10). We also investigated mice with a selective inactivation of either the N- or C-terminal
ACE catalytic domain. Our studies indicate that ACE plays a role in many other physiologic processes beyond simple blood pressure
control. |
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Keywords: | Angiotensin-converting enzyme Mice Gene targeting Tissue-specific expression Heart Macrophages |
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