细胞因子与基因治疗股骨头缺血性坏死的研究动态

股骨头缺血性坏死是由多种病因造成的股骨头缺血和骨细胞坏死的病理过程，是骨科难治疾病之一。近年来细胞因子与基因治疗作为新近发展起来的一项新技术在股骨头坏死的研究中应用颇多。多种细胞因子及其转导入种子细胞的基因可以不同程度促进血管重建与骨修复，从而恢复股骨头血供及修复骨坏死。目前的研究还多处于实验阶段，如何延长转入基因表达时间，如何选择一种低毒、低免疫反应载体与支架材料的选择等问题将成为以后研究的重点。

Research trends of cytokines and gene therapy for treating avascular necrosis of the femoral head

The treatment of avascular necrosis of the femoral head whose pathological procedure is femoral head avascularity and osteocyte necrosis induced by many etiological factors is one of the difficult subjects in orthopaedics. As a newly-developed technology, cytokines and gene therapy have been widely used in the research of avascular necrosis of the femoral head. Many cytokines and transduced genes have the effects of promoting vascular reconstruction and bone repairment so that it could recover the blood supply and repair the osteonecrosis of femoral heads. Most current researches remain in the experimental phase. Therefore, the research focus in the future comes down to the lengthening of gene transfection expression as well as the selection of vectors and tissue engineering bones that have low immunereaction and low toxicity.