Thrombopoietin-producing hepatocellular carcinoma |
| |
| Authors: | Ryu Tomiko Nishimura Satoshi Miura Hideaki Yamada Haruki Morita Haruhiko Miyazaki Hiroshi Kitamura Shigehiro Miura Yasusada Saito Toshikazu |
| |
| Institution: | Department of Internal Medicine, Social Insurance Chuo General Hospital, Tokyo. |
| |
| Abstract: | A 66-year-old man with hepatocellular carcinoma (HCC) showed marked thrombocytosis (110.7 x 10(4)/microl). Bone marrow (BM) aspirates demonstrated an increase of mature megakaryocytes (MgK). The serum thrombopoietin (TPO) level was increased to about 100-fold that of the normal level in the terminal stage. However, the platelet count gradually decreased to 13.5 x 10(4)/microl. The autopsy specimen revealed normoplastic BM with decreased MgK, mainly consisting of the immature type, and it was negative for tumor cells. Liver specimen showed markedly fatty metamorphosis. Immunohistochemical staining of TPO demonstrated that hepatocytes were weakly stained and HCC cells strongly stained, suggesting TPO-producing HCC. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
