Effects of repetitive transcranial magnetic stimulation on hypothalamic-pituitary-adrenal axis of patients with depression |
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Authors: | He Mingli Gu Zhengtian Wang Xinyi Tian Xiaoping |
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Institution: | [1]Department of Psychiatry & Neurology, Affiliated Lianyungang Hospital, Medical College of Xuzhou, Lianyungang 222002, China [2]Laboratory of Eleetroencephalography, Affiliated Lianyungang Hospital, Medical College of Xuzhou, Lianyungang 222002, China [3]Center of Laboratory Medicine, Affiliated Lianyungang Hospital, Medical College of Xuzhou, Lianyungang 222002, China |
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Abstract: | Objective: To investigate the effects of sleep electroencephalogram-modulated repetitive transcranial magnetic stimulation (SEM-rTMS) and conventional rTMS (C-rTMS) on the activity of hypothalamic-pituitary-adrenal (HPA) axis in patients with depression. Methods: In a double-blind, randomized controlled trial, 164 patients diagnosed with depression were randomized to treatment with SEM-rTMS (n=57), C-rTMS (n=55) or sham rTMS (n=52) for 30 min every day for 10 d. Before and after treatment plasma concentrations of adrenocorticotropic hormone (ACTH) and cortisol (CORT) were measured, and the 24-item Hamilton Depression Rating Scale (HAMD-24) was used for assessment. Results: The HAMD-24 scores and plasma ACTH and CORT concentrations of these depressive patients before treatment were significantly different from those of the normal control group (P0.05). The HAMD-24 scores and plasma ACTH and CORT concentrations in the SEM-r TMS group and conventional rTMS group were decreased significantly (P<0.05). There was a significant positive correlation between the HAMD-24 scores and plasma ACTH (n=240, r=0.105, P=0.048) and CORT concentrations (n=240, r=0.126, P=0.023) in the patients with depression before and after treatment. Conclusion: The antidepressant effect of rTMS, including SEM-rTMS, may be related to its decreasing HPA axis activity. (This trail was registered. No: ChiCTR-TRC-00000465) |
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Keywords: | Depression Transcranial magnetic stimulation Hypothalamic-pituitary-adrenal axis |
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