| 实验性脑损伤后脑组织内腺苷、肌苷含量的变化及其意义 |
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| 引用本文： | 童武松,卢亦成,江基尧. 实验性脑损伤后脑组织内腺苷、肌苷含量的变化及其意义[J]. 第二军医大学学报, 2000, 21(2): 111-113 |
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| 作者姓名： | 童武松 卢亦成 江基尧 |
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| 作者单位： | [1]解放军第411医院神经外科 [2]第二军医大学长征医院神经外科 |
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| 摘 要： | 研究大鼠急性脑损伤后腺苷含量变化及其生代代谢。方法：采用大鼠液压脑损伤模型,用高效液相色谱法测定大鼠脑损伤前后脑皮质内腺苷和肌苷含量。结果：大鼠脑损伤后１０ｍｉｎ,伤侧大脑皮质内腺苷含量即明显升高,与对伤后３０ｍｉｎ升至最高值,伤后２ｈ腺苷含量恢复正常水平。结论腺苷参与继发性脑损伤后的病理生理过程。
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| 关 键 词： | 颅脑损伤 腺苷 肌苷 高效液相色谱法 |
| 文章编号： | 0258-879X(2000)02-0111-03 |
| 修稿时间： | 1999-10-11 |
Contents changes of adenosine and inosine in cerebral cortex after experimental brain injury |
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| TONG Wu Song ,LU Yi Cheng ,JIANG Ji Yao ,ZHU Cheng ,XU Er Li. Contents changes of adenosine and inosine in cerebral cortex after experimental brain injury[J]. Former Academic Journal of Second Military Medical University, 2000, 21(2): 111-113 |
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| Authors: | TONG Wu Song LU Yi Cheng JIANG Ji Yao ZHU Cheng XU Er Li |
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| Affiliation: | TONG Wu Song 2,LU Yi Cheng 1,JIANG Ji Yao 1,ZHU Cheng 1,XU Er Li 3 |
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| Abstract: | Objective: To investigate the changes of adenosine concentration in cerebral cortex after experimental brain injury and its biochemical metabolism. Methods: In rat fluid percussion brain injury model, high performance liquid chromatography (HPLC) was used to measure the concentration of adenosine and inosine in brain cortex before and after trauma. Results: A sharp increase of adenosine concentration occurred immediately after brain injury. Thirty minutes after trauma the adenosine concentration reached the highest peak ( P <0.01), and returned to normal level 2 hours later. Inosine changed in the same way with the time of returning to normal level delayed slightly. Conclusion: Adenosine participates in the pathophysiology process after second brain injury. |
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| Keywords: | brain injuries chromatography high performance liquid adenosine inosine |
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