| 中药多靶点逆转白血病多药耐药机制研究 |
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| 引用本文： | 施叶叶,马程遥,苗筠杰,陈勇,陈建伟,李祥. 中药多靶点逆转白血病多药耐药机制研究[J]. 中草药, 2016, 47(7): 1230-1235 |
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| 作者姓名： | 施叶叶 马程遥 苗筠杰 陈勇 陈建伟 李祥 |
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| 作者单位： | 南京中医药大学药学院, 江苏 南京 210023;南京中医药大学药学院, 江苏 南京 210023;南京中医药大学药学院, 江苏 南京 210023;南京中医药大学药学院, 江苏 南京 210023;南京中医药大学药学院, 江苏 南京 210023;南京中医药大学药学院, 江苏 南京 210023 |
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| 基金项目： | 国家自然科学基金资助项目(81573577,81274057,81403182);江苏省高校优势学科建设工程资助项目(ysxk-2010);江苏省自然科学基金项目(BK2012853);国家教育部博士点专项基金资助项目(20113237110009);南京中医药大学青年科学基金(BXZR23);2015年江苏省普通高校研究生科研创新计划项目(1003) |
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| 摘 要： | 白血病是血液系统一种常见的恶性肿瘤,是国内十大高发恶性肿瘤之一。白血病的多药耐药是化疗失败的主要原因,化学药逆转剂通常毒副作用大,作用机制单一,制约着其临床应用。而中药有高效、低毒、多靶点的特点,在逆转多药耐药白血病上显示出其独特的优势。通过分析近些年白血病多药耐药的机制,综述中药单体成分、中药复方和单味药白血病多药耐药逆转剂,以探讨中药逆转白血病多药耐药的前景。
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| 关 键 词： | 白血病 多药耐药机制 中药 逆转剂 恶性肿瘤 |
| 收稿时间： | 2015-11-12 |
Mechanisms of Chinese materia medica multi-target to reverse MDR of leukemia |
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| SHI Ye-ye,MA Cheng-yao,MIAO Yun-jie,CHEN Yong,CHEN Jian-wei and LI Xiang. Mechanisms of Chinese materia medica multi-target to reverse MDR of leukemia[J]. Chinese Traditional and Herbal Drugs, 2016, 47(7): 1230-1235 |
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| Authors: | SHI Ye-ye MA Cheng-yao MIAO Yun-jie CHEN Yong CHEN Jian-wei LI Xiang |
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| Affiliation: | College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China |
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| Abstract: | Leukemia is a common malignant tumor in blood system, and it is one of the 10 high incidence malignant tumors in China. The main reason related to the failure of chemotherapy in leukemia is multidrug resistance(MDR). Chemical reversal agents often have the side effects and the mechanisms of chemical reversal agents are single, which restricts its clinical application. With efficiency, low-level toxicity, and multi-target points, Chinese materia medica shows its unique advantages in reversing MDR of leukemia. This paper summarizes the MDR mechanisms of leukemia and reversal agents in Chinese medicine in order to find more Chinese medicine to reverse leukemia. |
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| Keywords: | leukemia multidrug resistance mechanisms Chinese materia medica reversal agents malignant tumors |
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