| 以姜黄清脂分散片为模型药物研究吸水性在中药分散片崩解过程中的关键作用再验证 |
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| 引用本文： | 韩雪,李剑,韩丽,张定堃,张喻娟,马悦,杨明. 以姜黄清脂分散片为模型药物研究吸水性在中药分散片崩解过程中的关键作用再验证[J]. 中草药, 2016, 47(7): 1112-1117 |
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| 作者姓名： | 韩雪 李剑 韩丽 张定堃 张喻娟 马悦 杨明 |
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| 作者单位： | 成都中医药大学药学院 四川省中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137;成都中医药大学药学院 四川省中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137;成都中医药大学药学院 四川省中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137;成都中医药大学药学院 四川省中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137;成都中医药大学药学院 四川省中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137;成都中医药大学药学院 四川省中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137;江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004 |
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| 基金项目： | 国家自然科学基金资助项目(81274098,30973952);国家基础科学人才培养基金(J13100340-19) |
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| 摘 要： | 目的验证吸水性在中药分散片崩解过程中的关键作用,以期为中药分散片崩解迟缓的解决方法提供思路。方法以油性物料姜黄清脂分散片为研究对象,对不同原料药(姜黄清脂分散片、乳糖片)、不同辅料组成的姜黄清脂分散片以及微粉硅胶改性前后的姜黄清脂分散片的吸水性、崩解过程进行测定,对比分析研究吸水性对片剂崩解过程的影响。结果不同辅料处方[羧甲基淀粉钠(CMS-Na)、交联聚乙烯比咯烷酮(PVPP)、低取代羟丙基纤维素(L-HPC)、微晶纤维素(MCC)]的姜黄清脂片的吸水性均弱于乳糖片,其崩解过程也较慢;调整辅料比例后不同辅料处方姜黄清脂片的吸水性能排序为CMS-Na-PVPP(1∶1)PVPPCMS-Na,崩解过程排序也相同;微粉硅胶对姜黄提取物进行改性后以上3种辅料处方的吸水能力均增强,崩解时间明显缩短。结论研究证明了吸水性是影响中药分散片崩解的关键因素,采用微粉硅胶与原料药共研磨,是解决中药分散片崩解迟缓问题的重要工艺技巧。
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| 关 键 词： | 吸水性 中药分散片 崩解 粉体改性 姜黄清脂分散片 黏性 油性 微粉硅胶 |
| 收稿时间： | 2015-11-30 |
Revalidation of key role of water absorption in disintegration process of Chinese materia medica dispersible tablets:Exemplifying by Jianghuang Qingzhi Dispersible Tablets |
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| HAN Xue,LI Jian,HAN Li,ZHANG Ding-kun,ZHANG Yu-juan,MA Yue and YANG Ming. Revalidation of key role of water absorption in disintegration process of Chinese materia medica dispersible tablets:Exemplifying by Jianghuang Qingzhi Dispersible Tablets[J]. Chinese Traditional and Herbal Drugs, 2016, 47(7): 1112-1117 |
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| Authors: | HAN Xue LI Jian HAN Li ZHANG Ding-kun ZHANG Yu-juan MA Yue YANG Ming |
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| Affiliation: | Pharmacy College, Chengdu University of Traditional Chinese Medicine;Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China;Pharmacy College, Chengdu University of Traditional Chinese Medicine;Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China;Pharmacy College, Chengdu University of Traditional Chinese Medicine;Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China;Pharmacy College, Chengdu University of Traditional Chinese Medicine;Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China;Pharmacy College, Chengdu University of Traditional Chinese Medicine;Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China;Pharmacy College, Chengdu University of Traditional Chinese Medicine;Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China;Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China |
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| Abstract: | |
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| Keywords: | water absorption Chinese materia medica dispersible tablets disintegrating process powder modification Jianghuang Qingzhi Dispersible Tablets viscosity oiliness aerosil |
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