姜黄化学成分研究

目的研究姜黄Curcuma longa根茎的化学成分。方法采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱和HPLC等方法进行分离纯化,并根据理化性质、NMR、MS等波谱数据鉴定化合物的结构。结果从姜黄95%乙醇提取物的正丁醇部位分离得到13个化合物,分别鉴定为5-羟基没药酮(1)、环姜黄素(2)、环去甲氧基姜黄素(3)、异环去甲氧基姜黄素(4)、姜黄素(5)、去氧姜黄素(6)、阿魏酸甲酯(7)、香草醛(8)、对羟基苯甲酸(9)、4-(4-羟基苯基)-2-丁酮(10)、4-(4-羟基-3-甲氧基苯基)-2-丁酮(11)、4-(4-羟基苯基)-3-丁烯-2-酮(12)、4-(4-羟基-3-甲氧基苯基)-3-丁烯-2-酮(13)。结论化合物1为未见文献报道的新化合物,命名为5-羟基没药酮;化合物4为首次从该植物中分离得到。

Chemical constituents from rhizomes of Curcuma longa

Objective To study the chemical constituents in the rhizomes of Curcuma longa. Methods A variety of silica gel column chromatography, Sephadex LH-20 gel column chromatography, and HPLC methods were used for the separation and purification of chemical composition. Their structures were established on the basis of physicochemical property and spectral data. Results Thirteen compounds were obtained and identified as 5-hydroxyl-bisabolon-9-one(1), cyclocurcumin(2), demethoxyl cyclocurcumin(3), isodemethoxyl cyclocurcumin(4), curcumin(5), demethoxyl curcumin(6), methyl ferulate(7), vanillin(8), 4-hydroxyl benzoic aldehyde(9), 4-(4-hydroxyl phenyl)-2-butanone(10), 4-(4-hydroxyl-3-methoxyl phenyl)-2-butanone(11), 4-(4-hydroxyl phenyl)-3-buten-2-one(12), and 4-(4-hydroxyl-3-methoxyl phenyl)-3-buten-2-one(13). Conclusion Compound 1 is obtained as a new compound named 5-hydroxyl-bisabolon-9-one without reported in literature until now and compound 4 is first isolated from this plant.