无创性血糖的光谱检测及临床研究状况

对糖尿病患者的血糖浓度进行频繁的测定是对糖尿病控制的一个重要手段。用无创性探测技术进行血糖监测不仅可以免除患者的痛苦 ,消除某些在体测量葡萄糖的生物材料对人体的危害 ,还可以提高检测的频率 ,从而对血糖浓度进行更紧密的控制。这样就有可能形成一个含有监测器和胰岛素注射的封闭循环系统。但目前无创性血糖监测的光谱学基础知识还没有完整地建立起来。由于体内葡萄糖测量技术的复杂性 ,这方面设备的研制与当前技术的最高理论水平还存在着很大差距

Spectroscopic and clinical aspects of noninvasive blood glucose measurements

Frequent determination of glucose concentrations in diabetic patients is an important tool for diabetes management.Use of noninvasive(NI)detection techniques offers several advantages,such as the absence of pain and exposure to sharp objects and biohazard materials,the potential for increased frequency of testing and hence,tighter control of the glucose concentrations,and the potential for a closed loop system including a monitor and an insulin pump.But the spectroscopic basis for NI determination of blood glucose is not yet well established and most of data are based on in vitro experimentation.