Clinical Observation of High Dose Cinobufocini in Attenuation and Treatment of Infeclion and Granulocytopenia during Combined Chemoth

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Clinical Observation of High Dose Cinobufocini inAttenuation and Treatment of Infeclion andGranulocytopenia during Combined Chemotherapyof Malignant Blood Disease

The use of high dose cinobufocini in attenuation and treatment of infection and granulocy-topenia during combined chemotherapy was observed in patients with malignant blood diseases. Thestudy was designed in such a way that each patient served also as part of the control group. The testgroup included 18 males and 12 temales , ranged in ages between 16 and 66(averaged 34). Sixty-two ex-periments were run on 20 patients with acute leukemia, 8 with malignant lymphoma and 2 with multiplemyeloma. The test group was treated with high dosages of cinobufocini. In each case , instances ot infec-tion were signiticantly decreased and the number of granulocytes was not markedly changed by the treat-ment. The results of this study suggest that high dosage cinobufocini therapy may significantly reduce therisk of infection and the degree and duration of granulocytopenia associated with chemotherapy for malig-nant blood diseases. AIso, high dosage cinobufocini therapy is simple, convenient and causes little or noside effects.