新辅助化疗对乳腺癌ki67、cox-2、p53表达的影响及其临床意义 |
| |
引用本文: | 林其声,施雄文,徐书楷,蒋新宇.新辅助化疗对乳腺癌ki67、cox-2、p53表达的影响及其临床意义[J].中国当代医药,2009,16(24):13-14. |
| |
作者姓名: | 林其声 施雄文 徐书楷 蒋新宇 |
| |
作者单位: | 福建省三明市第二医院肿瘤科,福建医科大学临床教学专业基地,福建永安,366000 |
| |
摘 要: | 目的:探讨新辅助化疗对ki67、COX-2、p53表达的影响,分析表达变化与临床疗效的关系。方法:用免疫组化Envision法分别检测61例可手术的乳腺癌患者新辅助化疗前后ki67、cox-2、p53表达情况。结果:①术前新辅助化疗后,ki67、COX-2的表达明显下降,p53的表达变化无显著差异性改变。@ki67的高表达的患者新辅助化疗效果明显好于低表达,COX-2阴性的化疗效果优于cox-2阳性,p53阴性的化疗效果亦好于p53阳性的。结论:化疗前检测乳腺癌的ki67、cox-2、p53,可以指导新辅助化疗,并且是疗效判断的分子生物学指标。
|
关 键 词: | 乳腺癌 新辅助化疗 ki67 cox-2 p53 |
Effect of neoadjuvant chemotherapy on ki67,cox-2,p53 expression in breast cancer and its significance |
| |
Authors: | LIN Qisheng SHI Xiongweng XU Shukai JIANG Xinyu |
| |
Institution: | (Depatment of oncology, The second Hospital of Sanming city, Fujian Province, Yong'an 366000,China) |
| |
Abstract: | Objective: To study the effect of neoadjuvant chemotherapy on the expressions of ki670,cox-2,p53 in breast cancer tissues, and analyze the relationship between expression changes and efficency of neoadjuvant chemotherapy. Methods: The expression of the ki67,cox-2 and p53 in 61 patients with breast cancer were examined by immunohistochemical as say before and after neoadjuvant chelnotherapy. Results: ①After neoadjuvant chemotherapy, the expression ki67 ,cox-2 decreased significantly, but p53 showed no significant changes. ②Patients with high expression of ki67 were more likely respond to neoadjuvant chemotherapy. The effect of neoadjuvant chemotherapy had a significantly negative correlation with p53 and cox-2 expression. Conclusion: The results indicate that the expressions of ki67,cox-2,p53 are strong prognostic molecular markers and can be a guide for neoadjuvant chemotherapy. It is predication of prognosis for patients with breast cancer. |
| |
Keywords: | Breast cancer Neoadjuvant chemotherapy ki67 cox-2 p53 |
本文献已被 维普 万方数据 等数据库收录! |
|