不同中药注射剂对2型糖尿病并发急性脑梗死应激激素 …

目的：探讨不同中药注射剂对２型糖尿病并发急性脑梗死患者应激激素和免疫细胞因子的影响及其临床意义。和放射免疫分析法（ＲＩＡ）对使用蛇毒制剂（降纤酶）、刺五加及金钠多（银杏叶提取物）注射液３组病例（各为３２、２０、１２例）进行治疗前后促肾上腺皮质释放激素（ＣＲＨ）、促肾上腺皮质激素（ＡＣＴＨ）、皮质醇（ＣＳ）、肿瘤细胞坏死因子（ＴＮＦα）与白细胞介素－６（ＩＬ－６）含量检测。分析其变化特点，并与健康人

Effect of Different Injections of Chinese Herbal Medicine on Stress Hormones and Immune Cell Factors in Patients of Type 2 Diabetes Mellitus Complicated with Acute Cerebral Infarction

OBJECTIVE: To investigate the effect and clinical significance of different injections of Chinese herbal medicine on stress hormones and immune cell factors in treating patients of type 2 diabetes mellitus complicated with acute cerebral infarction. METHODS: Patients were divided into three groups, treated with Defibrase injection (DI, n = 32), Acanthopanax injection (AI, n = 20) and Ginaton injection (GI, n = 12) respectively. Parameters, including corticotropin-releasing hormone (CRH), adrenocoticortropic hormone (ACTH), cortisol (CS), tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) were determined using RIA in patients before and after treatment. The changes of parameters were analyzed and compared with those of healthy subjects for control. RESULTS: (1) Levels of all the above-mentioned parameters in all the three treated groups were higher than those in the healthy control group (P < 0.01); (2) All parameters were reduced after treatment in the three treated groups and the optimal effect was shown in the DI group (P < 0.01). CONCLUSION: The beneficial action of the three injections is closely related with the levels of stress hormones and immune cell factors, therefore, to monitor dynamically the changes of CRH, ACTH, CS, TNF alpha and IL-6 is of important significance in evaluation of therapeutic effect and elucidation of the pharmacology of Chinese herbal medicine.